Introduction: Brain injury induces an almost immediate response from glial cells, especially astrocytes. Activation of astrocytes leads to the production of inflammatory cytokines and reactive oxygen species that may result in secondary neuronal damage. Melatonin is an anti-inflammatory and antioxidant agent, and it has been reported to exert neuroprotection through the prevention of neuronal d...

Traumatic brain injury (TBI) is a common cause of death which affects millions of people around the world. TBI is also associated with various neurological impairments. After the primary mechanical injury at the moment of a TBI event, several cellular and molecular processes are activated within the brain tissue as the secondary injury. An important mechanism involved in the secondary injury of...

Abstract Date Presented 04/20/2023 This study explored drug and alcohol use among people with traumatic brain injury (TBI) in both rural urban areas. Study findings suggest that TBI from families reporting unmet needs engaged more frequent substance use. Primary Author Speaker: Steven Wheeler Additional Authors Speakers: Amanda Acord-Vira

OF DISSERTATION POST-TRAUMATIC SLEEP FOLLOWING DIFFUSE TRAUMATIC BRAIN INJURY By Rachel Kathleen Rowe Traumatic brain injury (TBI) is a major cause of death and disability throughout the world with few pharmacological treatments available for individuals who suffer from neurological morbidities associated with TBI. Cellular and molecular pathological processes initiated at the time of injury de...

brain edema plays an important role in secondary tissue damage following traumatic brain injury (tbi) but the underlying mechanisms are not entirely elucidated. the g protein coupled receptor fm-4 and its ligands, neuromedin s (nms) and neuromedin u (nmu), are expressed in diverse brain areas, and have a variety of roles in nociception, inflammation, and stress but their probable changes after ...

Introduction: The use of standard rodent model, allows for the understanding of neuronal injury physiopathology and helping development of therapeutic strategies. Because of eliminating technical problems, we designed a modified impactor device with ability to induce different degrees according to kilodyne from very mild to very severe of spinal cord injury (SCI) and traumatic brain injury (TBI...

Background & Aim: Traumatic brain injury is one of the main causes of death and disability. The aim of this study is to systematically review the articles which assessed some serum factors of traumatic brain injury patients in relation to their outcomes. Methods & Materials/Patients: Databases were searched for relevant publications from 2005 to 2014. Selection criteria were:Studies which ev...

Traumatic brain injury (TBI) is a global health concern that typically causes emotional disturbances and cognitive dysfunction. It elicits a complex secondary injury response, with neuroinflammation as a crucial central component. Secondary pathologies following TBI may be associated with chronic neurodegenerative disorders and an enhanced likelihood of developing dementia-like disease in later...

Abstract Objective Despite the strong evidence suggesting post-traumatic stress disorder (PTSD) symptoms negatively impact cognition following mild traumatic brain injury (TBI), little is known about this relationship in more severe TBI. This study investigates between PTSD and cognitive performance complicated mild, moderate, severe, penetrating Methods Participants were 137 U.S. military serv...

A special interest group of the American Congress of Rehabilitation Medicine [ACRM; Mild Traumatic Brain Injury Committee. (1993). Definition of mild traumatic brain injury. Journal of Head Trauma Rehabilitation, 8 (3), 86-87.] was the first organized interdisciplinary group to advocate four specific criteria for the diagnosis of a mild traumatic brain injury (TBI). More recently, the World Hea...