Using an animal model for insulin-dependent diabetes mellitus (IDDM), the NOD mouse, we have demonstrated that allogeneic bone marrow transplantation (BMT) has a preventative effect on IDDM, and that a combined transplantation of pancreas and bone marrow can be used to treat IDDM. We have also shown that BMT has a curative effect on systemic autoimmune disease in (NZB x NZW) F1, BXSB, and (NZW ...

nineteen patterns with cml have been transplanted in our bone marrow transplantation (bmt) section since 1991, the mean age of these patients was 26.05 (sd = 9.35). our conditioning regimen for these patients was cyclophosphamide 60mglkg for 2 days and busulfan 4mglkg for 4 consecutive days. eleven patients are still alive arid eight patients died during follow-up ranging from 6 months to 5 yea...

In a previous multicenter phase III trial comparing peripheral blood stem cell transplantation (PBSCT) to bone marrow transplantation (BMT) from HLA-matched related donors, we found no statistically significant difference in the cumulative incidence of clinical extensive chronic graft-versus-host disease (GVHD) in the 2 groups. We have analyzed the results in more detail to determine whether th...

In this article, we provide evidence that bone marrow transplantation (BMT) can be used to treat various otherwise intractable diseases. We also show which currently incurable diseases could be treated using our novel BMT methods.

During the last two decades conventional therapy has improved the prognosis of thalassemia. However, despite such improvement it still remains a progressive disease with treatment-related complications such as hepatitis, liver fibrosis, and cardiac disease. Bone marrow transplantation (BMT) can prevent or delay progression of the aforementioned complications. The importance of clinical research...

Bone marrow transplantation (BMT) represents a cure for nonmalignant hematological disorders. However, compared with the stringent conditioning regimens used when performing BMT to treat hematological malignancies, the reduced intensity conditioning regimen used in the context of nonmalignant hematological disorders leads to substantially higher rates of BMT rejection, presumably due to an inta...

Allogenic bone marrow transplantation (BMT) is a curative therapy for malignant and nonmalignant lymphohematopoietic diseases and other disorders. However, the development of secondary malignancies is an important complication among transplantation survivors. Patients who have undergone BMT have a 2to 8-fold higher risk of developing these cancers than the general population. After BMT, the mos...

A retrospective case-matched analysis was performed comparing 189 myeloma patients treated with allogeneic bone marrow transplantation (allo-BMT) with an equal number of patients who received autologous stem cell transplantation (ASCT). Matching was performed with respect to gender and number of treatment lines before transplantation. The groups were comparable with the exception of median age ...

In order to find out which anticancer drugs could utilize to the best advantage a syngeneic bone marrow transplantation in high-dose chemotherapy for cancer, we tested six drugs [nimustine hydrochloride (ACNU), Adriamycin, cyclophosphamide (CY), mitomycin c, vindesin, etoposide] in Sprague-Dawley rats from a standpoint of the beneficial effect of bone marrow transplantation (BMT). Two or three ...