Over the recent years there has been a gradual rise in the use of pharmaceuticals during pregnancy. Knowledge on placental drug transfer and metabolism has increased during the past decades as well. Investigation of the transplacental transfer of any therapeutically useful drug is essential to the understanding of its metabolic processes and is a prerequisite for its use during pregnancy. The p...

Pulmonary tumors were induced in mice that were suckled by mothers that received urethan during lactation. More induced tumors appeared in sucklings when urethan was injected into lactating mothers soon after delivery. When pregnant mice were treated with urethan during gestation and lactation their offspring had a significantly increased incidence of pulmonary tumors, and the number of tumors ...