BACKGROUND Congenital hypothyroidism (CH) is one of the most common preventable causes of mental retardation. One important challenge in understanding the epidemiology of CH is that some newborns will have transient CH, a temporary depression of thyroid hormone concentrations that can last from several days to several months. Studies from other countries have reported that 10 to 15% of children...

On the basis of strong clinical evidence, congenital hypothyroidism should be identified and treated early to avoid potentially profound cognitive deficits. On the basis of strong clinical evidence, the dose of levothyroxine is higher at early ages and progressively decreases into adulthood. On the basis of observational studies and consensus, children with congenital hypothyroidism and a eutop...

In response to published newborn-screening data that have shown an increase in the incidence (birth prevalence) rate of primary congenital hypothyroidism (CH) in the United States, a workshop was held in Atlanta, Georgia, on February 27 and 28, 2008, to examine this issue. Topics of the meeting included pathophysiology, medical management, and follow-up of CH; transient hypothyroidism (etiology...

We present a 42-year-old woman with concomitant transient hypothyroidism due to Hashimoto's thyroiditis, autoimmune hepatitis and isolated ACTH deficiency. Two months after ceasing prednisolone (5 mg/day) for uveitis, she was discovered incidentally to have liver dysfunction with hypergammaglobulinemia, later diagnosed as autoimmune hepatitis by histological examination of the biopsied liver. I...

Iodine deficiency is the most common cause of hypothyroidism worldwide but in areas of Iodine sufficiency, other causes including autoimmunity and iatrogenic factors are more common. During pregnancy, autoimmune thyroid disease, characterized by presence of specific thyroid auto antibodies, is mostly responsible for hypothyroidism. Such females, who often had previous history of repeated aborti...

The diagnosis on the basis of low serum thyroxine level wiJh high thyrotropin level of congenital pri1111lfY hypothyroidism in newborn screening programs fails to distinguish between transient hypothyroidism and ectopic thyroid, athyrosis, dyshormonogenesis, or transient hyperthyrotropinemill. The correct use of neonotol thyroid scintigraphy aids in making a specific anatomic diagnosis. We scan...

The thyroid hormone is essential for the proper development of the central nervous system (CNS). Hormone deficiency during CNS development causes neurological abnormalities in the brain. The hippocampus is one of the brain regions vulnerable to hormone deficiency, and the volume of dentate gyrus (DG) and cornu ammonis (CA) are reduced by transient hypothyroidism during CNS development. However,...

Iodine overload frequently leads to transient hyperthyrotropinemia or hypothyroidism, and rarely to hyperthyroidism in neonates. Iodine exposure can be prenatal, perinatal or postnatal. Herein we report two newborn infants who developed severe hypothyroidism due to iodine overload. The overloading was caused by excessive use of an iodinated antiseptic for umbilical care in the first case, and a...

background: congenital hypothyroidism (ch) considered a common endocrine disorder in iran. we report the epidemiologic findings of ch screening program in isfahan, seven years after its development, regarding the prevalence of transient ch (tch) and its screening properties comparing with permanent ch (pch). materials and methods: in this cross-sectional study, children with primary diagnosis o...