نتایج جستجو برای: transforming growth factor
تعداد نتایج: 1479409 فیلتر نتایج به سال:
Each of the effector CD4 T-cell lineages - Th1, Th2, and the more recently identified Th17 - arises from pluripotent naïve precursors whose developmental fate is largely controlled by cytokines that act in concert with antigenic signals. Remarkably, development of the Th17 lineage has been linked to that of regulatory T cells, which obviate or downregulate Th17 responses to preserve immune home...
OBJECTIVES The biological functions of transforming growth factor-β signaling that involves Smad proteins have not been previously investigated with respect to coronary artery bypass grafts. The aim of the present study was to observe the immunostaining of proteins that are related to this signaling pathway. METHODS Fifteen remnants of coronary artery bypass grafts, including nine saphenous v...
The same enzyme is responsible for the activation of transforming growth factor-beta-like signalling molecules and the processing of fibrillar procollagens. This finding implicates a metalloendoprotease in the control of cell behavior and matrix assembly during morphogenesis.
Overproduction of transforming growth factor-beta clearly underlies tissue fibrosis in numerous experimental and human diseases. Transforming growth factor-beta's powerful fibrogenic action results from simultaneous stimulation of matrix protein synthesis, inhibition of matrix degradation, and enhanced integrin expression that facilitates matrix assembly. In animals, overexpression of transform...
We have evaluated the possible involvement of TGF-beta in rheumatoid arthritis by assay of 16 cell-free synovial fluids for the presence of its active and "latent" forms. Evidence has been obtained for TGF-beta-like activity in synovial effusions by four criteria: (a) TGF-beta receptor competition, (b) soft-agar colony formation of AKR-2B and NRK-49F indicator cells, (c) immunological neutraliz...
Novel oral transforming growth factor-beta signaling inhibitor EW-7197 eradicates CML-initiating cells" (2016).
W ITHIN the past two years, there has been an exponential increase in research on transforming growth factor-beta (TGF-beta). ~ In this brief minireview, we cannot provide a detailed survey of this topic (see referenees 56 and 73 for other reviews). Rather, we will summarize some new results, indicative of the importance of this peptide as a multifunetional regulator of cellular activity. The t...
Little is known about the involvement of Smad-related molecules in the regulation of the Transforming Growth Factor (TGF)-beta signaling pathway during hepatocarcinogenesis, particularly with respect to preneoplastic lesions of a rat liver. The aims of this study were to investigate the localizations and temporal expressions of TGF-beta Receptor Type 1 (TGR1) and Smads during the promotion stag...
Effect on the canine Eck fistula liver of intraportal TGF-beta alone or with hepatic growth factors.
Transforming growth factor-beta canceled the hepatocyte proliferation caused by transforming growth factor-alpha when the two substances were mixed and administered through a disconnected central portal vein branch after creation of an Eck fistula. In contrast, transforming growth factor-beta had no antidotal action on the stimulatory effects of insulin or full test doses of insulinlike factor-...
Transforming growth factor (TGF)-beta is the prototype in a family of secreted proteins that act in autocrine and paracrine pathways to regulate cell development and function. Normal cells typically coexpress TGF-beta receptors and one or more isoforms of TGF-beta, thus the synthesis and secretion of TGF-beta as an inactive latent complex is considered an essential step in regula-ting the activ...
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