Transdermal administration of drugs is generally limited by the barrier function of the skin. Colloidal systems are one of the most contentious methods for transdermal delivery of active substances across the skin. The colloidal systems helps in overcoming the shortcomings associated with transdermal drug delivery systems and provide sustained and controlled release of drugs. This review presen...

The aim of the present study was to develop and investigate the feasibility of delivering Nebivolol as a transdermal patch by iontophoresis. The passive and electrically assisted transdermal delivery of Nebivolol hydrochloride by iontophoresis will improve the therapeutic efficacy and overcome the difficulties raised in oral drug delivery. Because of its extensive hepatic metabolism and low dos...

Melatonin, a pineal gland hormone can play an important role on circadian rhythms and worked as an internal sleep facilitator in human. Recently, melatonin was used as a drug for treatment of insomnia. The transdermal drug delivery is a good alternative for melatonin delivery because of its variable oral absorption, short half-life, highly first pass metabolism, and a favorable partition coeffi...

Transdermal drug delivery systems have evolved as a successful alternative to systemic drug delivery. Despite their relatively higher costs, transdermal delivery systems have proved advantageous for delivery of selected drugs, such as estrogens, testosterone, clonidine and nitro-glycerine. Transdermal delivery provides a leading edge over injectable and oral routes by increasing patient complia...

A transdermal patch is a medicated adhesive that applied to the skin contains medication intended be absorbed into bloodstream. This frequently encourages healing of body part has been hurt. Transdermal delivery allows for regulated drug release patient, resulting in less systemic side effects and, certain cases, increased efficacy over other dose forms. an advantage types such as oral, topical...

Transdermal drug delivery systems are involved in the continuous administration of drug molecules from the surface of the skin into the circulatory system. Such systems have proved advantageous for delivery of certain drugs, such as scopolamine, nicotine, nitroglycerine, and estradiol. Compared with oral administration, transdermal drug delivery offers better uniformity of drug concentrations i...

A new frontier in the administration of therapeutic drugs to veterinary species is transdermal drug delivery. The primary challenge in developing these systems is rooted in the wide differences in skin structure and function seen in species ranging from cats to cows. The efficacy of a transdermal system is primarily dependent upon the barrier properties of the targeted species skin, as well as ...

Transdermal drug delivery has made a notable contribution to medical practice, but has yet to fully achieve its potential as an alternative to oral delivery and hypodermic injections. While transdermal delivery systems would appear to provide an attractive solution for local and systemic drug delivery, only a limited number of drugs can be delivered through the outer layer of the skin. The most...

Development of transdermal system mainly focused on formulation and characterization of monolithic matrix type transdermal drug delivery system of diltiazem hydrochloride for the treatment of mild to moderate hypertension. In this study, seven formulations were prepared in different ratio of film forming polymers. Formulations TDDS1 to TDDS7 were composed of carboxy methyl cellulose, polyvinyl ...