OBJECTIVES To determine the levels of progesterone in plasma, red cells and saliva as well as pregnanediol-3-glucuronide excretion in postmenopausal women using transdermal progesterone creams. METHODS A double-blind placebo controlled study was carried out using 24 postmenopausal women. Creams (placebo, 20 or 40 mg progesterone/g) were applied twice daily for 3 weeks followed by 1 week witho...

1 Chemical transport through human skin can play a significant role in human exposure to toxic 2 chemicals in the workplace, as well as to chemical/biological warfare agents in the battlefield. 3 The viability of transdermal drug delivery also relies on chemical transport processes through the 4 skin. Models of percutaneous absorption are needed for risk-based exposure assessments and drug5 del...

It has been recognized that the vehicle in which a permeant is applied to the skin has a distinctive effect on the dermal and transdermal delivery of active ingredients. The cutaneous and percutaneous absorptions can be enhanced, e.g. by an increase in thermodynamic activity, supersaturation and penetration modifiers. Furthermore, dermal and transdermal delivery can be influenced by the interac...

Pharmacokinetic-pharmacodynamic (PK-PD) models for percutaneous absorption are useful in evaluating the clinical performance and optimizing the design of transdermal therapeutic systems [1, 2]. Diffusion models have been developed in order to analyze diffusivity and partitioning of drugs in the skin [3, 4]. However, there are few in silico approaches for predicting the clinical performance as w...

The present article is a descriptive study of the performances of ethosomes and proniosomes as specialized delivery systems for transdermal drug delivery system. Vesicular systems, such as ethosomes and proniosomes are used in cosmetic and pharmaceutical products to encapsulate ingredients, to protect ingredients from degradation, to increase bioavailability, and to improve cosmetic performance...

BACKGROUND Cellulite is the accumulation of subcutaneous fat and connective tissue in tights and buttocks. Xanthines, such as aminophylline, are used as phosphodiesterase inhibitors, and are also adenosine receptor antagonists. OBJECTIVES The aim of the present study was to characterize in vitro aminophylline transdermal absorption through shed snake skin, and to investigate the absorption en...

Topical ethanol is used as a dermal penetration enhancer in some commercial products. Previous studies have demonstrated that chronic ethanol consumption can also disrupt skin barrier function, leading to increased transdermal penetration. This observation becomes much more relevant if a single drinking episode induces similar changes. The purpose of this study was thus to examine the transderm...