To the Editor: We found the recent report by Liu et al1 using transcript profiling to examine genes regulated by insulin growth factor-1 interesting because of the biological and technological issues it raises. We applaud the efforts of the investigators to begin to address critically important and often neglected areas of microarray technology such as specificity and reproducibility. However, ...

I n each volume of the Journal, the editors select one article for our Beyond the Manuscript post-study interview with the authors. Beyond the Manuscript provides the authors the opportunity to tell listeners what they would want to know about the project beyond what went into the final manuscript. The associate editors who handled the articles conduct our Beyond the Manuscript interviews. Haer...

Welcome to Progress in Community Health Partnerships’ latest episode of our Beyond the Manuscript podcast. In each volume of the Journal, the editors select one article for our Beyond the Manuscript post-study interview with the authors. Beyond the Manuscript provides the authors the opportunity to tell listeners what they would want to know about the project beyond what went into the final man...

F indings on page 747 suggest that multiple subunits of coiled-coil proteins may meet even before each subunit is fully translated. The article from Chang et al. reveals that the precursors to intermediate fi laments (IFs) assemble at tiny translation factories containing several mRNAs. Dimers of IFs, such as the neuronal protein peripherin, form into higher-order assemblies. Before they form f...

In each volume of the Journal, the editors select one article for our Beyond the Manuscript post-study interview with the authors. Beyond the Manuscript provides the authors the opportunity to tell listeners what they would want to know about the project beyond what went into the final manuscript. The associate editors who handled the articles conduct our Beyond the Manuscript interviews. This ...

Rezension von Madame Bovary c’est nous – Lektüren eines Jahrhundertromans. Hgg. Marijana Erstić, Gregor Schuhen, Christian Tschilschke. Bielefeld: Transcript 2021, 246 S.

Fidelity of template-dependent nucleic acid synthesis is the main determinant of stable heredity and error-free gene expression. The mechanism (or mechanisms) ensuring fidelity of transcription by DNA-dependent RNA polymerases (RNAPs) is not fully understood. Here, we show that the 3' end-proximal nucleotide of the nascent transcript stimulates hydrolysis of the penultimate phosphodiester bond ...

Sex-lethal ( Sxl) gene products induce female development in Drosophila melanogaster and suppress the transcriptional hyperactivation of X-linked genes responsible for male X-chromosome dosage compensation. Control of Sxl functioning by the dose of X-chromosomes normally ensures that the female-specific functions of this developmental switch gene are only expressed in diplex individuals. Althou...