Since methotrimeprazine proved to be both an effective tranquilizer and analgesic, its effect in a tranquilizing dose of 0.15 mg/kg on the arterial blood gases was determined in human volunteers. Because of the known potentiating effect of some phenothiazines on the narcotic-analgesic induced respiratory depression and analgesia, the effect of methotrimeprazine on the meperidine-induced respira...

• It has become apparent that the use of general anesthesia for some types of hemodynamic investigations introduces changes which may limit application of the results to normal physiology. The importance of this point has been emphasized by Rushmer and his colleagues and studies of unanesthetized animals have been published by several authors in recent years. Certainly most cardiovascular exper...

introduction: preoperative psycho emotional preparation of patients is one of the principle purposes of anesthesia which can be achieved by administration of premedications. children should receive premedication before entering the operating room due to their dependence on parents and the fear and anxiety of separation from parents. different drugs are administered for this purpose, but conside...

The carcinogenesis potential of ripazepam , a benzodiazepine derivative, was studied in mice and rats for 78 and 104 weeks, respectively. Groups of 50 male and 50 female CD1 mice and CD rats each were given doses of 15 and 150 mg/kg of ripazepam in the diet. Survival rates were adequate for statistical analysis. Significant suppression of body weight gains occurred in rats but not in mice given...

Introduction: Nardostachys jatamansi DC. is an important ayurvedic plant. The root and rhizome contain active compounds with carminative, sedative, antispasmodic and tranquilizing properties. It is also used as an insect repellent. Essential oil from the drug shows antimicrobial activity against a number of microorganisms. Method: The present study comprises microscopic and macroscopic studies,...

BACKGROUND The purposes of this study were to investigate the prevalence of psychotropic (hypnotic, antidepressant, and anxiolytic) drug use among adolescents aged 15-16 years during the period 2006-2010 according to gender and subcategories of psychotropics, and to study psychotropic drug use over the period 2007-2010 among incident users in 2007. METHODS This was a one-year prevalence and f...

Diclofenac sodium is a very common drug used in medical practice for analgesia and is freely available over the counter without any medical prescription. The drug is also the most commonly used or misused by quacks working all over India. Many case reports have been published on upper limb catastrophe of unintentional intra-arterial injection of barbiturates, thiopental sodium, narcotics, and t...

OBJECTIVE Evaluate nonmedical use (NMU) of ADHD prescription stimulants (Ritalin(®), Adderall(®), Adderall(®) XR, Concerta(®), and Vyvanse(®)) in a U.S. adult general population sample. METHOD In all, 10,000 adults (aged 18-49) from an online, opt-in panel, proximity matched to U.S. Census demographics, were surveyed to assess NMU prevalence, routes of administration (ROA), reasons for NMU, a...