نتایج جستجو برای: traf6 و murf1

تعداد نتایج: 762113  

2016

ش ي ر ي ن ي فسو ي نا 1 (M.Sc) ، س ي د ما ي د انعر يي س ي تدا 1 (Ph.D) ، ونهد ناسحا ي 1 و 2 (Ph.D) ، قتدمحم ي جرب ي نا ـنجورب ي 1 (M.Sc) زاـنرف ن ي دازك نانمج ي 1 و 3 (M.Sc) 1 هاگشناد هش ي د تشهب ي ، هدكشناد ي سدنهم ي ژرنا ي روانف و ي اه ي ون ي ،ن امزآ ي هاگش بونان ي ژولونكتو ي ، ب هورگ ي ژولونكتو ي 2 هاگشناد برت ي ت هدكشناد ،سردم ي ز مولع ي تس ي 3 هاگشناد ملا...

2009
Shenhav Cohen Jeffrey J. Brault Steven P. Gygi David J. Glass David M. Valenzuela Carlos Gartner Esther Latres Alfred L. Goldberg

Loss of myofibrillar proteins is a hallmark of atrophying muscle. Expression of muscle RING-finger 1 (MuRF1), a ubiquitin ligase, is markedly induced during atrophy, and MuRF1 deletion attenuates muscle wasting. We generated mice expressing a Ring-deletion mutant MuRF1, which binds but cannot ubiquitylate substrates. Mass spectrometry of the bound proteins in denervated muscle identified many m...

2017
Hirohito Shimizu Adam D Langenbacher Jie Huang Kevin Wang Georg Otto Robert Geisler Yibin Wang Jau-Nian Chen

Altered Ca2+ handling is often present in diseased hearts undergoing structural remodeling and functional deterioration. However, whether Ca2+ directly regulates sarcomere structure has remained elusive. Using a zebrafish ncx1 mutant, we explored the impacts of impaired Ca2+ homeostasis on myofibril integrity. We found that the E3 ubiquitin ligase murf1 is upregulated in ncx1-deficient hearts. ...

Journal: :Circulation research 2009
Monte S Willis Jonathan C Schisler Luge Li Jessica E Rodríguez Eleanor G Hilliard Peter C Charles Cam Patterson

Muscle ring finger (MuRF)1 is a muscle-specific protein implicated in the regulation of cardiac myocyte size and contractility. MuRF2, a closely related family member, redundantly interacts with protein substrates and heterodimerizes with MuRF1. Mice lacking either MuRF1 or MuRF2 are phenotypically normal, whereas mice lacking both proteins develop a spontaneous cardiac and skeletal muscle hype...

2009
Nedal T. Ratrout Syed Masiur Rahman

إ ةيرهجملا جماربلا لمشي اذهو ،ةيرورملا ةآرحلا ةاآاحم جمارب روطت يف مهاس ةيتامولعملا ايجولونكتلا يف ريبكلا مدقتلا ن ) Microscopic ( ، نلا ىلع بلطلا ةاآاحم اًضيأ لمشي نايحلأا ضعب يفو ، تاعطاقتو قرط نم اهيف امب لقنلا ةموظنم ةاآاحمب حمسيل يللآا بساحلا تاقيبطت قاطنو لق . ةيرهجملا ةيرورملا ةآرحلا ةاآاحم جمارب نيب نراقتو عجارت ةقرولا هذهو ) Microscopic ( ةيلومشلاو ) Macroscopic ( فلاتخلاا هجوأ ىلع ةزآر...

2010
Siegfried Labeit Christine H. Kohl Christian C. Witt Dittmar Labeit Jeong Jung Henk Granzier

MuRF1 is a member of the TRIM/RBCC superfamily, a gene family that encompasses a large variety of proteins, all sharing the conserved TRIM (Tripartite Motive) sequential array of RING, B-box, and coiled-coil domains. Within this family, MuRF1(also named TRIM63) is a specialized member that contributes to the development of muscle atrophy and sarcopenia. Here we studied MuRF1's role in muscle at...

Journal: :Cancer research 2013
Heng Sun Xue-Bing Li Ya Meng Li Fan Min Li Jing Fang

TNF receptor (TNFR)-associated factor TRAF6 is a key activator of NF-κB, playing a critical role in the regulation of innate immune responses and their connection to adaptive immune responses. TRAF6 interactions determine receptor-induced cell death versus survival. TRAF6 has been implicated in cancer but its contributions have not been investigated deeply. In this study, we show that TRAF6 upr...

Journal: :Muscle & nerve 2014
Amber L Pond Carrie Nedele Wen-Horng Wang Xun Wang Claire Walther Christine Jaeger Kevin S Bradley Huahua Du Naoya Fujita Gregory H Hockerman Kevin M Hannon

INTRODUCTION We investigated the mechanism by which the MERG1a K+ channel increases ubiquitin proteasome proteolysis (UPP). METHODS Hindlimb suspension and electro-transfer of Merg1a cDNA into mouse gastrocnemius muscles induced atrophy. RESULTS Atrophic gastrocnemius muscles of hindlimb-suspended mice express Merg1a, Murf1, and Mafbx genes. Electrotransfer of Merg1a significantly decreases...

2013
Heng Sun Xue-Bing Li Ya Meng Li Fan Min Li Jing Fang

TNF receptor (TNFR)–associated factor TRAF6 is a key activator of NF-kB, playing a critical role in the regulation of innate immune responses and their connection to adaptive immune responses. TRAF6 interactions determine receptor-induced cell death versus survival. TRAF6 has been implicated in cancer but its contributions have not been investigated deeply. In this study, we show that TRAF6 upr...

2017
Xiao Juan Wang Jing Jing Xiao Lei Liu Hong Chao Jiao Hai Lin

The ubiquitin-proteasome system (UPS)-dependent proteolysis plays a major role in the muscle catabolic action of glucocorticoids (GCs). Atrogin-1 and muscle-specific RING finger protein 1 (MuRF1), two E3 ubiquitin ligases, are uniquely expressed in muscle. It has been previously demonstrated that GC treatment induced MuRF1 and atrogin-1 overexpression. However, it is yet unclear whether the hig...

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