Control of vehicle traction is of utmost importance in providing safety and obtaining desired vehicle motion in longitudinal and lateral vehicle control. Vehicle traction control systems can be designed to satisfy various objectives of a single vehicle system or a platoon of vehicles in an automated highway system, which include assuring ride quality and passenger comfort. Other objectives are ...

In many pathological conditions the endothelium becomes activated and dysfunctional, resulting in hyperpermeability and plasma leakage. No specific therapies are available yet to control endothelial barrier function, which is regulated by inter-endothelial junctions and the generation of acto-myosin-based contractile forces in the context of cell-cell and cell-matrix interactions. However, the ...

Growth cones are required for the forward advancement and navigation of growing axons. Modulation of growth cone shape and reorientation of the neurite are responsible for the change of outgrowth direction that underlies navigation. Change of shape involves the reordering of the cytoskeleton. Reorientation of the neurite requires the generation of tension, which is supplied by the ability of th...

Michael W. Hudoba, Carlos E. Castro Introduction Biological cells navigate their environment by exerting a field of traction forces applied via a multitude of localized attachment points to the surrounding extracellular matrix termed focal adhesion sites. During cellular migration, the cell cytoskeleton protrudes forward in the direction of motion, adheres to the extracellular matrix, and then ...

The traction force produced by biological cells has been visualized as distortions in flexible substrata. We have utilized quantitative phase microscopy by digital holography (DH-QPM) to study the wrinkling of a silicone rubber film by motile fibroblasts. Surface deformation and the cellular traction force have been measured from phase profiles in a direct and straightforward manner. DH-QPM is ...

Traction force microscopy (TFM) is a quantitative technique for measuring cellular traction force, which is important in understanding cellular mechanotransduction processes. Traditional TFM has a significant limitation in that it has a low measurement throughput, commonly one per TFM dish, due to a lack of cell position information. To obtain enough cellular traction force data, an onerous wor...

I The forces required to detach the retina from the pigment epithelium and the subsequent structural changes were studied toith a device that produced retinal traction at different rates over localized, equatorial areas of freshly enucleated owl monkey and albino rabbit eyes. Sloio traction (0.2 to 0.8 mm. per minute) produced higher and larger retinal detachments and bigger tears in both types...

To understand how the mechanical properties of tissues emerge from interactions of multiple cells, we measure traction stresses of cohesive colonies of 1-27 cells adherent to soft substrates. We find that traction stresses are generally localized at the periphery of the colony and the total traction force scales with the colony radius. For large colony sizes, the scaling appears to approach lin...