The inclusion of aminotransferase and alkaline phosphatase (AP) determination within routine laboratory tests for patients in both primary care and hospital care has brought about an increase in the detection of symptomatic-stage liver disturbances. Viral hepatitis is the most common cause of aminotransferase elevation, and accounts for more than 90% of acute hepatitis. Diagnosis is easily conf...

After decades of research, the nature of the rate-limiting step in the folding of globular proteins still elicits a range of opinions (1). The properties of the associated transition state (TS) provide critical insights into possible folding mechanisms. However, the characterization of the TS is challenging because atomic level methods cannot be applied to this minimally populated state, and lo...

Liver toxicity or otherwise toxic hepatitis occurs when liver develops inflammation because of exposure to a toxic substance. Liver is a vital organ engaged in several vital functions, including removing most drugs and chemicals from the bloodstream, and breaking them down so that they can be quickly eliminated from the body. Breaking down toxins creates byproducts that can be highly damaging t...

The authors present a case of recurrent acute liver failure because of occupational exposure to organic solvents. A 35-year-old man with a 3-week history of worsening jaundice and flu-like symptoms was admitted to our hospital. Viral hepatitis serology and autoimmune factors were negative. The authors considered liver transplantation, but the patient's liver function spontaneously recovered. Li...

Latarea Hepatitis (Labrea Black Fever) is a severe liver disease found in several hamlets of the Amazon Region, where microepidemics are reported. This morbid condition is known to occur specifically in this region, where chil­ dren and young adults are mainly affected.-. The clinical picture is similar to that seen in fulminant forms of viral and toxic hepatitis, and courses with a high degree...

Marked activity of cobalt-activated acylase was found in the sera of 33 of 37 patients with acute toxic hepatitis due to poisoning with either amanita mushrooms or chemicals. The activity of the enzyme showed a positive correlation with that of serum transaminases, reached the highest levels on the patient's admission to hospital and within a few days fell rapidly to undetectable levels. Slight...

Marked activity of cobalt-activated acylase was found in the sera of 33 of 37 patients with acute toxic hepatitis due to poisoning with either amanita mushrooms or chemicals. The activity of the enzyme showed a positive correlation with that of serum transaminases, reached the highest levels on the patient's admission to hospital and within a few days fell rapidly to undetectable levels. Slight...

Type 1 interferons (IFN) protect the host against viruses by engaging a cognate receptor (consisting of IFNAR1/IFNAR2 chains) and inducing downstream signaling and gene expression. However, inflammatory stimuli can trigger IFNAR1 ubiquitination and downregulation thereby attenuating IFN effects in vitro. The significance of this paradoxical regulation is unknown. Presented here results demonstr...

This article presents a rare case of acute toxic hepatitis in thirty-one-year old primigravida. In the 36th week of gestation, the patient was introduced nitrofurantoin 100 mg a day due to symptoms of dysuria and enterococcus isolated from urine culture. After induced delivery at term because of hypertension, repeated laboratory findings showed increased aspartate aminotransferase (AST) and ala...