Ependymomas accounts for about 2%–6% of CNS and 60%–70% of spinal cord tumors. Several histological patterns of these neoplasms are well known, but little attention has been devoted to a variant composed of giant cells. In spite of apparently “worrisome” histology, giant cell ependymoma seems to be a neoplasm with a relatively good prognosis. This report presents a case of giant cell ependym...

central giant cell granulomas (cgcgs) may manifest as radiolucencies anywhere in the mandible or maxilla. in rare cases, it can appear as a localized periradicular area and mimic an endodontic lesion. this case report presents an uncommon location of cgcg which was not accurately diagnosed nor timely treated. periodic follow ups of periapical radiolucencies after rct are necessary. dentists sho...

the b cell is a vital contributor to humoral immunity. the b cell-specific antigen cd20 is expressed during b cell development, starting at the pre-b cell level and persists through b cell differentiation, but is lost during terminal differentiation to plasma cells. rituximab is a monoclonal antibody that destroys both normal and malignant b cells that have cd20 on their surfaces and is therefo...

Background: Giant cell tumor is a benign but locally aggressive bone neoplasm which uncommonly involves the skull. Giant cell tumor (GCT) of the sphenoid bone is relatively rare. In this report, we describe a tumor of the greater wing of left sphenoid bone. Case presentation: A 31-year-old female was presented with headache, proptosis and diplopia of her left eye. Cranial magnetic resonance ima...

PURPOSE The aim of this study was to report a case of Adult-Onset Asthma with Periocular Xanthogranulomas (AAPOX) associated with systemic IgG4-related disease (IgG4-RD). OBSERVATIONS A 57-year-old man presented with bilateral periorbital swelling for 1 year. Histopathology of a left orbital biopsy showed fibro vascular connective tissue inundated with foamy, lipid-laden histiocytes and touto...

Erdheim-Chester disease is a rare non-Langerhans form of histiocytosis with multiple organ involvement. Approximately 20% of patients have xanthoma-like lesions, usually on the eyelids. We report a case of Erdheim-Chester disease in a 32-year-old male who showed peculiar xanthomatous skin lesions and also had atopic dermatitis. His skin manifestations included ring-like yellowish tumors on his ...

  Two rare cases of extra-articular diffuse variant giant cell tumor of the tendon sheath are presented, at the elbow of a 68-year-old female and the foot of a 56-year-old male. Both patients presented with a palpable masses and marginal excision was performed; histological sections confirmed the diagnosis of extra-articular giant cell tumor. No adjuvant therapy was administered. At the last fo...

Abstract We present the case of an 84-year-old woman referred with a 6-month history lesion on her occipital scalp. Examination revealed creamy-white, nonscaly nodule measuring 15 × mm surface telangiectasia. Her past medical included basal cell carcinoma, stage 3 kidney disease, cardiovascular disease and osteoporosis. A diagnosis necrobiotic xanthogranuloma (NXG) was confirmed incisional biop...