background evaluation of operational risk is a consequential goal in perioperative management of patients in cardiac surgery. preoperative total lymphocyte count (ptlc) is a prognostic criterion of adverse major cardiovascular outcomes. objectives the purpose of this study was to investigate the prognostic value of ptlc as an independent predictor of postoperative morbidity and mortality in car...

Using vegetable protein sources as a replacement for fish meal (FM) in the diet of Pacific white shrimp (PWS) has negative impact on their health. Acute hepatopancreatic necrosis disease (AHPND), caused by Vibrio parahaemolyticus, affects PWS and causes financial losses. Nucleotides modulate immune response could contribute to counteracting these issues. Our objective was evaluate effects nucle...

Cuticular structures of arthropods undergo dramatic molt-related changes from being soft to becoming hard. The shell-hardening process of decapod crustaceans includes sclerotization and mineralization. Hemocyte PPO plays a central role in melanization and sclerotization particularly in wound healing in crustaceans. However, little is known about its role in the crustacean initial shell-hardenin...

In Drosophila, defense against foreign pathogens is mediated by an effective innate immune system, the cellular arm of which is composed of circulating hemocytes that engulf bacteria and encapsulate larger foreign particles. Three hemocyte types occur: plasmatocytes, crystal cells, and lamellocytes. The most abundant larval hemocyte type is the plasmatocyte, which is responsible for phagocytosi...

The involvement of circulating hemocytes as the principal cellular effector mediating molluscan immune responses is well established. They participate in a variety of internal defense-related activities including microbial phagocytosis, multicellular encapsulation, and cell-mediated cytotoxicity reactions that are presumed to be initiated through foreign ligand binding to hemocyte receptors and...

Parameters of hemocyte populations have been considered as relevant indicators of bivalve health and are currently used in immunotoxicological studies. Hemocytes in hemolymph can be collected by puncturing either the pericardial cavity or the adductor muscle sinus with a syringe. Flow cytometry is a methodological approach that is increasingly being used in laboratories for the study of hemocyt...

schistosomiasis is the second most common parasitic cause of death, after malaria. biomphalaria glabrata is a fresh water snail with medical importance since it is the intermediate host of schistosoma mansoni, an agent of schistosomiasis. the internal defense system of b. glabrata snails is mostly represented by circulating elements of the hemolymph, hemocytes, which are important factors in fi...

?-glucan is considered as an effective immunostimulant because of its binding capacity to different receptors on leukocytes leading the stimulation immune responses including bactericidal activity, cytokine productivity, and survival fit ability at cellular levels. In response cell surface receptors, stimulates release cytokines chemokines. It has been found that these signaling proteins eventu...

Hemolymph is the circulating fluid of insects and is a key component of their immune system. However, little is known concerning hemocyte identification, development, differentiation and related cellular immune responses. The present study aimed to determine whether a hemocyte extract prepared from Bombyx mori larvae had anti‑inflammatory effects; THP‑1 (a human monocytic leukemia cell line) ce...

Drosophila larvae defend themselves against parasitoid wasps by completely surrounding the egg with layers of specialized hemocytes called lamellocytes. Similar capsules of lamellocytes, called melanotic capsules, are also formed around "self" tissues in larvae carrying gain-of-function mutations in Toll and hopscotch. Constitutive differentiation of lamellocytes in larvae carrying these mutati...