PURPOSE The aim of the present research was to formulate a transparent microemolsion as a topical delivery system for tretinoin for the treatment of acne. METHODS Microemulsion formulations prepared by mixing appropriate amount of surfactant including Tween 80 and Labrasol, co-surfactant such as propylene glycol (PG) and oil phase including isopropyl myristate - transcutol P (10:1 ratio). The...

The main objective of this study is to formulate Bromfenac Microemulsion with prolonged duration of action which will help in increasing its topical bioavailability. Bromfenac belongs to the category of NSAID. A calibration curve of Bromfenac was taken in USP Phosphate buffer pH 7.4 at 268nm. Oleic acid, Poloxamer 188 and Propylene glycol were found to have maximum absorbance during solubility ...

Article history: Received on: 09/10/2014 Revised on: 27/10/2014 Accepted on: 18/11/2014 Available online: 29/12/2014 The objective of present study was to formulate hydrogel thickened Lornoxicam transdermal formulation. Eutectic mixture of camphor and menthol was chosen as oily phase (maximum 10%), solvent for Lornoxicam and powerful penetration enhancer. Tween 80, ethanol and Carbopol 934p, HP...

The aim of the present work was to develop a ME for topical delivery of Amphotericin B (AmB). Microemulsions (MEs) are versatile systems to solubilize drugs due to the presence of both a hydrophobic and a hydrophilic region, as well as a distinctive interface composed of surfactant and cosurfactant. MEs have been reported for many advantages for topical application of drugs. Considering that Am...

To the Editor: We prepared a case report entitled ‘Suspected Anaphylactic Reaction Associated with a Microemulsion of Propofol during Anesthesia Induction’ (1). However, one reviewer commented that we should have considered midazolam (2), remifentanil (3), rocuronium (4), ephedrine (5), dexamethasone (6), epinephrine (7), poloxamer 188 (8), and polyethylene glycol (9) in addition to a microemul...

Fungal infections have become a major problem of worldwide concern. Yeasts belonging to the Candida genus and the pathogenic fungus Cryptococcus neoformans are responsible for different clinical manifestations, especially in immunocompromised patients. Antifungal therapies are currently based on a few chemotherapeutic agents that have problems related to effectiveness and resistance profiles. M...