BACKGROUND Desquamative gingivitis (DG) is a clinical condition characterized by red, painful, glazed, and friable gingiva, which might be a manifestation of some autoimmune mucocutaneous diseases. The time from the development of initial signs of DG to diagnosis can vary from months to years. Based on a literature search, no data concerning patients with DG without signs of autoimmune disease ...

The most widely prescribed drugs for the treatment of a variety dermatoses are Topical corticosteroids (TC). These medications approved inflammatory and pruritic manifestations dermatologic disorders due to their powerful symptom-relieving impact. Clobetasol propionate (CP) is popular (TC) used relieve itching, redness, oedema caused by skin disorders. Anti-inflammatory, anti-pruritic, vasocons...

The valued studies of alternative psoriasis treatment options are in a much higher need among the Scientific Community. This study aimed to evaluate anti-psoriatic activity ursolic acid cream imiquimod-induced BALB/c mice. creams containing acid, pentacyclic triterpenoid at percentages 0.1 and 0.2% were formulated. pH, spreadability, physical characteristics acute dermal irritation assessed. An...

PURPOSE The assessment of the degree of skin blanching following the application of a formulation containing a topical corticosteroid has been established as a surrogate method for the determination of bioequivalence. In this study, both visual and chromametric assessments have been carried out on two topical creams containing clobetasol propionate (0.05%) and the results from both methods are ...

Multiphoton microscopy has emerged in the past decade as a promising tool for noninvasive skin imaging. Our aim was to evaluate the potential of multiphoton microscopy to detect topical corticosteroids side effects within the epidermis and to provide new insights into their dynamics. Healthy volunteers were topically treated with clobetasol propionate on a small region of their forearms under o...

Topical application of clobetasol propionate in a strength of 0-05% in cream or ointment (Dermovate) suppressed the hypothalamic-pituitary-adrenal axis in both normal people and patients with diseased skin. In normal people the 9 am serum cortisol level was suppressed when between 45 and 90 g was applied weekly. Insulin stress test results in patients with diseased skin showed an abnormally sma...

We herein report two cases of eosinophilic annular erythema in adults, which is rare. In both patients, lesions developed rapidly in few days and were located mainly on the trunk, buttocks, and extremities. Diagnosis was histopathological, with typical features including acute dermal inflammatory infiltrate with abundant eosinophils. One of the patients recurred after treatment on three occasio...

With the institution of antiretroviral therapy, psoriasis can be controlled with topical treatments, such as clobetasol and calcipotriene and ultraviolet light. Before adequate immune reconstitution under antiretroviral therapy occurs or in cases of complex or more severe psoriasis, treatment with the retinoid agent acitretin at 10 to 25 mg/d can be considered; it should be noted that this agen...