CD103 Restrains Treg Migration in Inflamed Skin See article p. 551 Glutamine Inhibition Affects CD8 T Cell Outcomes 563 Suramin Neutralizes Histones 648 Ablating CCR8+ Tregs Enhances CD8+ Tumor Response 673

Top is a most remarkable particle, even for a quark. A single top quark weighs 175 GeV/c 2 , about as much as an atom of gold. But unlike the gold atom, which can be disassembled into 79 protons, 79 electrons, and 118 neutrons, top seems indivisible, for we discern no structure at a resolution approaching 10 −18 m. Top's expected lifetime of about 0.4 yoctosecond (0.4× 10 −24 s) makes it by far...

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We argue that intelligible appeals to interlevel causes (top-down and bottom-up) can be understood, without remainder, as appeals to mechanistically mediated effects. Mechanistically mediated effects are hybrids of causal and constitutive relations, where the causal relations are exclusively intralevel. The idea of causation would have to stretch to the breaking point to accommodate interlevel ...

1. Fried TR, Tinetti ME, Towle V, O’Leary JR, Iannone L. Effects of benefits and harms on older persons’ willingness to take medication for primary cardiovascular prevention. Arch Intern Med. 2011;171(10):923-928. 2. Leipzig RM, Whitlock EP, Wolff TA, et al; US Preventive Services Task Force Geriatric Workgroup. Reconsidering the approach to prevention recommendations for older adults. Ann Inte...