BACKGROUND Tooth decay is the most common paediatric disease and there is a serious paediatric tooth decay epidemic in Alaska Native communities. When untreated, tooth decay can lead to pain, infection, systemic health problems, hospitalisations and in rare cases death, as well as school absenteeism, poor grades and low quality-of-life. The extent to which population-based oral health intervent...

Transposon mutagenesis coupled with next-generation DNA sequencing (Tn-seq) is a powerful tool for discovering regions of the genome that are required for the survival of bacteria in different environments. We adapted this technique to the dental caries pathogen Streptococcus mutans UA159 and identified 11% of the genome as essential, with many genes encoding products required for replication, ...

Caries disease in human teeth is a that permanently destroys the inner walls of and forms small holes teeth. The Indonesian people lack knowledge to find information identify tooth decay, which makes many unaware consequences dangers this disease. Tooth decay usually caused by three factors. first factor saliva, are hosts microorganisms oral cavity. Bacteria food second third purpose research h...