Carboxylic acids may be metabolized to acyl glucuronides and acyl-coenzyme A thioesters (acyl-CoAs), which are reactive metabolites capable of reacting with proteins in vivo. In this study, the metabolic activation of tolmetin (Tol) to reactive metabolites and the subsequent formation of Tol-protein adducts in the liver were studied in rats. Two hours after dose administration (100 mg/kg i.p.),...

OBJECTIVES To explore serum and tissue pharmacodynamics of linezolid versus vancomycin against methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates with different MBC/MIC ratios. METHODS Five strains (vancomycin MIC/MBCs, mg/L) were used: TOL-1 (2/≥64), TOL-2 (1/16), LT-1 and LT-2 (1/8) and NT (1/2). The linezolid MIC/MBC for all strains was 2/≥64 mg/L. A two-compartment dynam...

Drought is the most destructive environmental limitation that jeopardizes agronomic production. Given wide range of industrial and medicinal applications arugula (Eruca sativa. L.), present study evaluated response a world collection 64 genotypes to drought stress over two-year period (2019 2020) through selection indices some traits. The main objective was identify best from Susceptibility Ind...

in order to study drought tolerance indices and to introduce tolerant maize hybrids in drought conditions, an experiment was conducted at the experimental field of seed and plant improvement institute, in 2009. the experiment was carried out using split-plot in a randomized complete block design (crbd) with three replications. the main plots consisted of three levels of irrigation regimes (irri...

A numerical algorithm is presented for solving one nonlinear equation in one real variable. Given Fx with brackets A and B, i.e., sign(T^) = -sign^g) * 0, the algorithm finds a zero of F, A < X < B. Alternately, a crossover pair is found, i.e., (X, Y): sign(Fx) = signify) * 0 where there is no floating-point number in the system between X and Y. This feature allows full use of machine precision...

OBJECTIVE The first Phase I study of autologous tolerogenic dendritic cells (Tol-DCs) in Type 1 diabetes (T1D) patients was recently completed. Pancreatic islet transplantation is an effective therapy for T1D, and infusion of Tol-DCs can control diabetes development while promoting graft survival. In this study, we aim to systematically review islet allograft survival following infusion of Tol-...

The recombinant plasmid RP4-TOL was transferred into Caulobacter crescentus at a high frequency, and the plasmid was maintained for at least 50 generations. C. crescentus cells which contained RP4-TOL grew on all the aromatic compounds that the plasmid normally allowed Pseudomonas putida to grow on. Reciprocal transfers from C. crescentus donor to P. putida or Escherichia coli recipients were l...

We present an adaptive multilevel Monte Carlo (MLMC) method for weak approximations of solutions to Itô stochastic differential equations (SDE). The work [Oper. Res. 56 (2008), 607–617] proposed and analyzed an MLMC method based on a hierarchy of uniform time discretizations and control variates to reduce the computational effort required by a single level Euler–Maruyama Monte Carlo method from...

BACKGROUND Offering a trial of labor (ToL) after previous caesarean section (CS) is an important strategy to reduce short- and long-term morbidity associated with repeated CS. We compared maternal and perinatal outcomes between ToL and elective repeat caesarean section (ERCS) at a district hospital in rural Rwanda. METHODS Audit of women's records with one prior CS who delivered at Ruhengeri ...