Overactive bladder (OAB) is a common problem whose prevalence increases with advancing age and compromises ­health-related­quality­of­life.­Tolterodine­was­the­first­antimuscarinic­drug­specifically­designed­to­treat­OAB. Through­MEDLINE,­we­reviewed­articles,­standardization­reports­and­meeting­abstracts,­published­between­2001­and­2011,­on­the­efficacy and tolerability of Tolterodine extended...

PURPOSE The present study was carried out to establish the accuracy of modern ultrasonographic techniques in the follow up of patients with superficial bladder carcinoma and to evaluate the patients tolerability of cystoscopy. METHODS Thirty-three patients with a history of superficial bladder carcinoma under active surveillance were initially examined using transabdominal ultrasound followed...

BACKGROUND A key challenge to dose selection in early central nervous system (CNS) clinical drug development is that patient tolerability profiles often differ from those of healthy volunteers (HVs), yet HVs are the modal population for determining doses to be investigated in phase II trials. Without clear tolerability data from the target patient population, first efficacy trials may include d...

Since the introduction of monoamine oxidase inhibitors (MAOIs) in the 1950s, researchers have been searching for antidepressant agents with more favorable tolerability profiles. The introduction of selective serotonin reuptake inhibitors (SSRIs) in the late 1980s provided clinicians with a drug class featuring an improved tolerability profile as compared to MAOIs and tricyclic antidepressants (...

BackgroundBerotralstat (BCX7353) is a recently approved, oral, once-daily kallikrein inhibitor for hereditary angioedema (HAE) prophylaxis. In the APeX-2 trial, berotralstat reduced HAE attack rates over 24 weeks, with favorable safety and tolerability profile.ObjectiveEvaluate safety, tolerability, effectiveness 48 weeks.MethodsAPeX-2 phase 3, parallel-group, multicenter trial (NCT03485911) in...

UNLABELLED A single center, open-label, dose-finding adaptive study was conducted in twelve healthy overweight female subjects. The study was to evaluate the safety and tolerability of the capsaicinoids (CAPs) from Capsicum extract in a beadlet form compared to placebo in a healthy overweight population. The investigational product capsaicinoids (CAPs) from Capsicum extract in a beadlet form (C...

PURPOSE To evaluate the tolerability on healthy volunteers and the efficacy on subjects affected by chronic moderate/severe blepharitis of a 5% glycyrrhizin and copolymer poly(ethylene glycol)/poly(propylene glycol)(PEG/PPG) ophthalmic solution. METHODS The study was a randomized, controlled, open label, intra-patient monocentric study. It consisted of two different phases, the assessment of ...