In plants infected with Potato leafroll virus (PLRV), or other luteoviruses, infection is very largely confined to cells in the vascular system. Even in tobacco plants transformed with PLRV full-length cDNA, in which all mesophyll cells should synthesize infectious PLRV RNA transcripts, only a minority of the mesophyll cells accumulate detectable amounts of virus. We have explored this phenomen...

Oral cancer is a highly lethal disease and one of the most debilitating and disfiguring of all malignancies in the world. According to Global Adult Tobacco Survey (GATS) 2010 report, 60% of tobacco users in India use only smokeless tobacco. Among 206 million smokeless tobacco users, 65.1 million are consuming gutkha. In recent years, gutkha is recognized as a life threatening disorder with the ...

Cigarette smoke and smokeless tobacco extracts contain multiple carcinogenic compounds, but little is known about the mechanisms by which tumors develop and progress upon chronic exposure to carcinogens such as those present in tobacco products. Here, we examine the effects of smokeless tobacco extracts on human oral fibroblasts. We show that smokeless tobacco extracts elevated the levels of in...

Background: Smoking is the largest preventable cause of death in the world, killing nearly 6 million people annually. This article is an investigation of measures implemented laws in the Iran to study the proposed strategy of control and reduce tobacco use based on the monitor, protect, offer, warn, enforce and raise (MPOWER) policy.Methods: All laws approved by the Parliament along with the in...

this study was carried out to evaluate tobacco dust concentration and also designing a suitable ventilation system for reduction of tobacco dust concentration in a tobacco processing factory in the north of iran.gravimetric method was used to determine the tobacco dust concentrations in the emission sources an also indoor workplace. a local exhaust ventilation system was designed according to t...

background: passive or environmental smoking is one of the important health problems, to which many adults and children are exposed in involuntary status. methods: in this hospital based case-control study, household exposure to tobacco smoke as an estimate of passive smokers was conducted in hamadan, western iran. the purpose was to find the relationship between environmental smoking and incid...

Cytotoxic properties of tobacco smoke are associated with chronic tobacco-related diseases. The cytotoxicity of tobacco smoke can be tested with short-term predictive assays. In this study, we compare eight mainstream cigarette smoke condensates (CSCs) from commercial and experimental cigarettes in three different cytotoxicity assays with unique and overlapping endpoints. The CSCs demonstrated ...

BACKGROUND The mechanisms behind the development of systemic immunomodulation among tobacco smokers are not fully understood, but several studies have indicated a role for CD8+ and/or CD4+ T cells. Interleukin (IL)-16, a cytokine released from inflammatory cells as well as bronchial epithelial cells, can recruit and activate CD4+ T cells. A study was undertaken to establish whether the IL-16 le...

Increased cost of tobacco cultivation is a major concern for its sustainable production in Iran. Therefore, the development of tobacco mechanized cultivation is a necessity. Given this, the driving and inhibiting factors of the development of mechanized tobacco cultivation were investigated by the Delphi technique in three rounds in Guilan Province, Iran. Nineteen experts from the Jahad Agricul...