Biochemical study of thymus leukemia antigen (TL) from thymocytes of various Tla genotypes and from leukemia cells revealed features that, given present evidence, are peculiar to TL among class I products of the H-2:Qa:Tla region of chromosome 17. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) of TL from thymocytes of all TL+ mouse strains, precipitated by anti-TL antiseru...

Cell surface antigens of the thymus-leukemia (TL) 1 system in the mouse are detectable only on thymocytes and cells of certain leukemias {1-3). Although TL antigens are not expressed on thymocytes of all mouse strains, leukemias developing in T L strains may be phenotypically TL+, suggesting that TL structural genes may be present in all mouse strains, and possibly in all cells (2). The appeara...

Transcript leaders (TLs) can have profound effects on mRNA translation and stability. To map TL boundaries genome-wide, we developed TL-sequencing (TL-seq), a technique combining enzymatic capture of m(7)G-capped mRNA 5' ends with high-throughput sequencing. TL-seq identified mRNA start sites for the majority of yeast genes and revealed many examples of intragenic TL heterogeneity. Surprisingly...

This paper studies knowledge representation in multi-agent environment. We investigate technique for computation truth-values of statements based at new temporal, agent’s-knowledge logic TL Dist . A logical language, mathematical symbolic models and a temporal logic TL KnI,U Dist based at these models are suggested. We find an algorithm which computes theorems of TL Dist and satisfiability of s...

We prepared ophthalmic formulations containing 0.5% tranilast (TL) nanoparticles using 0.005% benzalkonium chloride (BAC), 0.5% D-mannitol, and 2-hydroxypropyl-β-cyclodextrin (HPβCD), and investigated their usefulness in the ophthalmologic field by evaluating corneal toxicity and permeability. TL nanoparticles were prepared using zirconia beads and Bead Smash 12, which allowed the preparation o...

OBJECTIVE Sterilization (tubal sterilization and vasectomy) is a widely applied contraceptive method worldwide. Although most studies have described sterilization as a safe method, there are reports of tubal ligation (TL) and vasectomy complications. The aim of this study was to evaluate the effects of TL and vasectomy on the serum oxidative stress, specifically prooxidant-antioxidant balance (...

Telomere maintenance dysfunction has been implicated in the pathogenesis of Idiopathic Pulmonary Fibrosis (IPF). However, the mechanism of how telomere length is related to fibrosis in the lungs is unknown. Surgical lung biopsies of IPF patients typically show a heterogeneous pattern of non-fibrotic and fibrotic areas. Therefore, telomere length (TL) in both lung areas of patients with IPF and ...

BACKGROUND Telomere length (TL) has been found to be associated with life span in birds and humans. However, other studies have demonstrated that TL does not affect survival among old humans. Furthermore, replicative senescence has been shown to be induced by changes in the protected status of the telomeres rather than the loss of TL. In the present study we explore whether age- and sex-specifi...

Thymus-leukemia (TL) antigens are expressed in murine lymphocytes under strict developmental regulation. To elucidate the molecular basis of TL expression, we have identified the molecular species that react with TL antiserum. At least three species can be resolved by metabolic radiolabeling of thymocytes and ASL1 leukemia cells, lysis, immune precipitation, and sodium dodecyl sulfate-polyacryl...

We study pfaffian analogues of immanants, which we call pfaffinants. Our main object is the TL-pfaffinants which are analogues of Rhoades and Skandera’s TL-immanants. We show that TL-pfaffinants are positive when applied to planar networks and explain how to decompose products of complementary pfaffians in terms of TL-pfaffinants. We conjecture in addition that TL-pfaffinants have positivity pr...