The quantitative analysis of tizanidine hydrochloride in both pharmaceutical dosage form and bulk medication has been developed validated using an easy, affordable, quick, unique isocratic HPLC approach. Tizanidine was separated isocratically Waters symmetry C18 ODS as the stationary phase (250×4.6 mm, 5μm particle size), a flow rate 1.0 ml/min, UV detector to track eluate at 230 nm. drug its d...

Academic Dissertation To be presented, with the permission of the Medical Faculty of the University of Helsinki, for public examination in the small lecture hall

An endeavor has been made to create buccoadhesive bilayered tablets comprising of drug containing bioadhesive layer and drug free backing layer to release the drug for extended period of time with reduction in dosing recurrence. Tablets of Tizanidine hydrochloride were prepared by direct compression method using bioadhesive polymer tamarind seed gum with backing layer of ethyl cellulose. The ph...

There is a lack of data regarding the abuse liability of centrally acting non-opioid analgesics (NOA) and muscle relaxants (MR). A comparison of data retrieved from a German pharmacovigilance database (BfArM; accessed May 2013) and data from the literature concerning the abuse liability of NOA and MR approved in Germany was performed. The BfArM-database demonstrated cases of abuse only for clon...

A 55 years old, hypertensive, diabetic lady presented with sudden onset jerky movement of lower trunk and legs. It was present both in awake and sleep and got aggravated by mental stress as well as sensory stimulation. Examination revealed rhythmic jerks affecting muscles of lower abdomen and legs. The lower limbs had normal muscle bulk and power, increased tone, exaggerated deep tendon reflexe...