Three indirect methods for the assay of flunarizine dihydrochloride (FNH) in bulk drug and commercial formulation based on titrimetric and spectrophotometric techniques using bromate-bromide mixture are described. In titrimetry, a measured excess of bromate-bromide mixture is added to an acidified solution of FNH and the unreacted bromine is determined iodometrically (method A). Spectrophotomet...

For the first time sequential injection analysis (SIA) technique has been employed for titrimetry. A new SI titrimetric spectrophotometric method for the assay of vitamin C in drug formulations was explored. The method is based on the oxidation reaction of vitamin C with cerium(IV) in sulfuric acid media using a spectrophotometer as a detector with the wavelength monitored at 410 nm. A 2(3) fac...

Christensen and Facer (1) have devised an apparatus and procedure for the microdetermination of carbon and hydrogen in organic compounds by a wet combustion process in which the evolved carbon dioxide is absorbed in standard barium hydroxide. The apparatus used for the determination is based on the principle of Pettenkopfer (cf. (2)) in which the carbon dioxide is drawn into an evacuated vessel...

Unrestricted and reckless use of antibiotics has resulted in their accumulation in environment. This, in turn, has led to the emergence of multiple drug-resistant microbes. The present study focuses on degradation of ciprofloxacin (CIP) by an edible white rot fungus Pleurotus ostreatus. Effect of CIP was determined on radial growth and biomass of P. ostreatus. Titrimetric and spectrophotometric...

HE MAJOR METHODS CURRENTLY IN USE for the determination of uric cid in biologic fluids are the colorimetric (1-3), the titrimetric (4), and he enzymatic (5-7). All of these methods are performed directly on the luid to be measured and are therefore subject to the effects of interfering ubstances present in these fluids. Since the colorimetric and titrimetric echnics depend on the reducing abili...

One titrimetric and two spectrophotometric methods are described for the determination of ketotifen fumarate (KTF) in bulk drug and in tablets using cerium(IV) as the oxidimetric agent. In titrimetry (method A), the drug was treated with a measured excess of cerium(IV) in H2SO4 medium and after a standing time of 10 min, the surplus oxidant was determined by back titration with iron(II). The sp...