Stem cells are self-renewing cells that can be differentiated into other cell types. Conventional in vitro models for studying stem cells differentiation are usually preformed in two-dimensional (2D) cultures. The design of three-dimensional (3D) in vitro models which ideally are supposed to mimic the in vivo stem cells microenvironment is potentially useful for inducing stem cell derived tissu...

peripheral nerve injuries caused by traffic accidents, resections of tumors or iatrogenic side effects of the surgeries are few of the most common form of trauma occurring with up to 500,000 cases each year in iran. conventional strategies including nerve coaptation, and the application of autografts, allografts and xenografts are restricted due to the limited availability of donors, immune-rej...

In this study, mechanical properties and apatite formation ability of synthesized fluorapatite-hardystonite (FA-HT) nanocomposite scaffolds were investigated. Hardystonite (HT; 5 and 10 wt.%) as a reinforcement phase was incorporated into the FA scaffold. FA was mixed with HT for 4 h under argon gas at 220 °C. A space holder method was used for fabricating porous FA-HT scaffolds. Sodium chlorid...

Background and Aims: Cartilage is a very specific tissue, which does not have the capacity to heal and renew itself. Although the invention of the method of surgery with autologous chondrocyte transplantation, developed tools to treat the cartilage lesions, it couldn’t gain a great success due to problems such as damage to the area of donation. Using the mesenchymal stem cells derived from adip...

Bone disorders are of significant worry due to their increased prevalence in the median age. Scaffold-based bonetissue engineering holds great promise for the future of osseous defects therapies. Porous composite materials andfunctional coatings for metallic implants have been introduced in next generation of orthopedic medicine for tissueengineering. While osteoconductive materials such as hyd...

One of the major challenges in the field of tissue engineering is the production of scaffolding in nano-scale. The study of structural-functional connections in pathological and normal tissues with biologically active alternatives or engineered materials has been developed. Extracellular Matrix (ECM) is a suitable environment consisting of gelatin, elastin and collagen types I, II and III, etc....