Although studies in vivo revealed promising results in bone regeneration after implantation of scaffolds together with osteogenic progenitor cells, basic questions remain how material surfaces control the biology of mesenchymal stem cells (MSC). We used human MSC derived from bone marrow and studied the osteogenic differentiation on calcium phosphate surfaces. In osteogenic differentiation medi...

OBJECTIVE In this paper we present our observation of a specific sign on transvaginal ultrasound that may help basic minimal invasive surgeons diagnose vesico-uterine adhesions preoperatively. METHODS The ultrasound images of the latest eleven patients who were preoperatively diagnosed with vesico-uterine adhesions using transvaginal ultrasound were compared with their intraoperative findings...

Cell-matrix adhesions are of great interest because of their contribution to numerous biological processes, including cell migration, differentiation, proliferation, survival, tissue morphogenesis, wound healing, and tumorigenesis. Adhesions are dynamic structures that are classically defined on two-dimensional (2D) substrates, though the need to analyze adhesions in more physiologic three-dime...

OBJECTIVE To assess the efficacy and complications of surgical repair of incisional hernias by grafting of polypropylene mesh surrounded by fibrous tissue, compared to polypropylene mesh. METHODS twenty-five male and female Wistar rats were divided into two groups: control and experimental. The 15 animals of the experimental group underwent implantation of the mesh in the subcutaneous tissue....

Open reduction internal fixation (ORIF) metal plates provide exceptional support for unstable bone fractures; however, they often result in debilitating soft-tissue adhesions and their rigid shape cannot be easily customized by surgeons. In this work, a surgically feasible ORIF methodology, called AdhFix, is developed combining screws with polymer/hydroxyapatite composites, which are applied sh...

BACKGROUND Post-operative adhesion formation is a major clinical problem. Tissue oxygenation is one of the most important determinants in adhesion formation. The objective of this study was to investigate whether supplemental perioperative oxygen could reduce post-operative adhesion formation through increasing the peritoneal tissue oxygen tension (PitO(2)) in a mouse model. METHODS Adult C57...

Introduction Flexor tendon injuries caused by deep lacerations to the hands are a challenging problem for tissue engineers. Such injuries often result in debilitating adhesions, scar tissue that prevents the normal gliding motion of the flexor tendons through their lubricating synovial sheaths, preventing the hands from opening and closing. Evidence exists that tendon adhesions as well as scarr...

OBJECTIVES Adhesion formation continues to be an important problem in gastrointestinal surgery. In recent years, methylene blue (MB) has been reported to be an effective agent for preventing peritoneal adhesions. However, its effects on the wound healing process are unknown. In the present study, we investigated the effects of MB on the early and late phases of anastomotic wound healing and on ...

Acute gastric dilatation (AGD) is caused by mechanical and non-mechanical stomach processes. appendicitis affects children treated with surgery. Intussusception proximal bowel invagination against the distal bowel. Clinical findings of intussusception in form intermittent abdominal pain, a palpable mass abdomen, accompanied wine-red stools. Due to significant morbidity mortality, multiple-probl...

The wide range of epithelial cell shapes reveals the complexity and diversity intracellular mechanisms that serve to construct their morphology regulate functions. Using mechanosensitive steps, cells can sense a variety different mechanochemical stimuli adapt behavior by reshaping morphology. These changes shape rely on structural reorganization in space time generates modifications tensional s...