Around the world, species from the genus Tilia are commonly used because of their peripheral and central medicinal effects; they are prepared as teas and used as tranquilizing, anticonvulsant, and analgesic agents. In this study, we provide evidence of the protective effects of organic and aqueous extracts (100 mg/kg, i.p.) obtained from the leaves of Tilia americana var. mexicana on CCl4-induc...

Variations in fruits morphology of Tilia spp. were studied along longitudinal and altitudinal range. Ten populations of Tilia spp.from Golestan, Mazandaran and Gilan Provinces (N. Iran) were selected. After biometrical measurements and Scanning Electron Microscopic (SEM), Cluster Analysis divided the population into seven groups. Discriminat Analysis showed that among all traits studied, size o...

We present a prototype of a new structural classification of proteins, SCOP2 (http://scop2.mrc-lmb.cam.ac.uk/), that we have developed recently. SCOP2 is a successor to the Structural Classification of Proteins (SCOP, http://scop.mrc-lmb.cam.ac.uk/scop/) database. Similarly to SCOP, the main focus of SCOP2 is to organize structurally characterized proteins according to their structural and evol...

OBJECTIVES Earlier experiments have revealed that a single pretreatment of the rat with chlorphenvinphos (CVP) at a subtoxic dose (1.0 mg/kg, about 1/10 of DL50) makes the animal hyposensitive to the locomotor stimulating effect of amphetamine (AMPH) or scopolamine (SCOP) given three weeks postexposure. Such a hyposensitivity did not develop after a single or multiple (at short intervals) dosin...

In this study, our aim was to clarify the ameliorative effects of zeatin, a development hormone in plants. Zeatin mitigated cognitive deficits and showed AChE inhibition in scopolamine (Scop)-induced mice following 21 d of zeatin treatment. After administration of Scop for 30 min, each mouse performed Y-maze and step-down latency tasks as a check on immediate against cognitive function. The res...

UNLABELLED PREMISE OF THE STUDY Microsatellite markers in the genus Tilia were developed to investigate the genetic variation in T. platyphyllos and its relationship with T. cordata. • METHODS AND RESULTS Fifteen microsatellite markers were developed using a microsatellite enrichment protocol. Most loci show a high level of polymorphism in two T. platyphyllos populations from France. The n...

GABAergic projections terminate on numerous hippocampal interneurons containing calcium binding proteins (CBPs), including calbindin D‑28k (CB), calretinin (CR) and parvalbumin (PV). Memory deficits and expression levels of CB, CR, and PV were examined in the hippocampal subregions following systemic scopolamine (Scop; 1 mg/kg) treatment for 4 weeks in mice. Scop treatment induced significant m...

SCANPS performs iterative profile searching similar to PSI-BLAST but with full dynamic programing on each cycle and on-the-fly estimation of significance. This combination gives good sensitivity and selectivity that outperforms PSI-BLAST in domain-searching benchmarks. Although computationally expensive, SCANPS exploits onchip parallelism (MMX and SSE2 instructions on Intel chips) as well as MP...