OBJECTIVE To investigate the molecular mechanisms underlying the influence of alteration of iodine trapping on the prognosis of metastatic papillary thyroid carcinomas, focusing on the expression of the Na+/I(-) symporter (NIS). DESIGN We evaluated the expression of the NIS gene in a series of 11 enlarged neck lymph-node metastases of papillary thyroid carcinomas, including four patients in w...

I would like to comment that parathyroid scanning is performed with a lipophilic cationic complex of Tc, called sestamibi, and not free technetium pertechnetate, as is described in the article. According to the guidelines, dual phase Tc-sestamibi scans are commonly used for preoperative localization of parathyroid adenomas. Hyperactive parathyroid cells have a high concentration of sestamibi an...

introduction: medullary thyroid carcinoma (mtc) is a rare thyroid cancer secreting calcitonin (ct) which is the most sensitive and specific tumor marker for mtc. this type of thyroid cancer is able to metastasize to different body areas including regional lymph nodes, lungs, liver and bone. the aim of this study was to assess the sensitivity and specificity of [99mtc-dmsa (v)] whole body scan (...

A 39 year old female presented with rapidly enlarging goitre, minimal obstructive symptoms and no constitutional symptoms. Clinical examination revealed diffusely enlarged, firm, non-tender thyroid gland. Biochemical investigations showed subclinical hypothyroidism, positive thyroid antibodies and unremarkable inflammatory markers. Ultrasound examination and CT scan of the neck were suspicious ...

Introduction: In spite of large number of studies regarding relation between thyroid cancer and childhood irradiation, contraversy still exists management of these patients. This study tries to find optimal method of thyroid evaluation in this group. Methods and patients: In a recall program using mass media in Khorasan, all patients with childhood irradiation were invited for thyroid eva...

A49-year-old female presented to the hospital with abdominal pain and emesis. A computed tomography (CT) scan revealed a small-bowel obstruction and a right ovarian mass measuring 4.6 cm. Following oophorectomy, histopathology revealed a mature cystic teratoma with multiple foci of benign thyroid tissue, as well as a 0.9 cm focus of follicular variant papillary thyroid cancer (Figs. 1 and 2) su...

The H-scan analysis of ultrasound images is a matched-filter approach derived from analysis of scattering from incident pulses in the form of Gaussian-weighted Hermite polynomial functions. This framework is applied in a preliminary study of thyroid lesions to examine the H-scan outputs for three categories: normal thyroid, benign lesions, and cancerous lesions within a total group size of 46 p...

INTRODUCTION Cauda equina secondary to metastatic follicular thyroid cancer of the lumbosacral area is a rare entity. CASE REPORT We report an unusual case of a 52-year-old male who presented with backache, lower limb weakness, and perianal numbness. A CT-scan of the lumbosacral area showed an enhancing mass at the L4, L5 and S1 vertebrae. Histopathology after excision revealed a metastatic t...