Introduction: Curcuma amada Roxb. usually referred as ambahaldi is an exceptionally aromatic rhizomatic herb which contains number of phyto constituents responsible for several pharmacological activities. Present study attempt to explore antioxidant and analgesic activity ethanolic extract C. amada. Objectives: The goal this work was assess the Methods: For in-vitro study, DPPH (2, 2-Diphenyl-1...

background and objective: due to the presence of some evidence for anti-diabetic and antioxidant activity of tribulus terrestris (tt), this study was designed to investigate the anti-nociceptive effect of tt in streptozotocin-diabetic rats using formalin test and hot tail immersion tests. materials and methods: rats were divided into control, tt-treated control, diabetic, sodium salicylate (ss)...

BACKGROUND Hybanthus enneaspermus (HE) leaves are being used traditionally to relieve pain, and scientific studies have demonstrated their analgesic potential. This study attempted to elucidate the pharmacological mechanism(s) involved in the analgesic action of ethanol extract of H. enneaspermus leaves (EEHE). MATERIALS AND METHODS Forty-two male Wistar rats were separately randomized into s...

conclusions eoao showed an analgesic effect that may involve both the central and peripheral nervous systems. background the althaea officinalis (marshmallow) plant is traditionally used to treat skin burns and constipation and to reduce inflammation. objectives the aim of this study was to evaluate the acute and chronic analgesic effects of the essential oil of althaea officinalis leaves (eoao...

OBJECTIVE Recently, we observed wound healing activity of 50% ethanol extract of Mallotus philippinensis Muell. Arg (MP) fruit hairs extract (MPE). In several intestinal infections, localized inflammation is of common occurrence and hence we evaluated the anti-inflammatory, analgesic and hypnotic activity of MPE in different rat experimental models. MATERIALS AND METHODS Anti-inflammatory act...

The current study addressed two important concerns, one pertinent to the impact of PDE-5 inhibitor (tadalafil) on morphine-induced analgesia and the second relevant to its influence on morphine-induced oxidative stress in two different pain models, the the tail-flick test (representing an acute thermal phasic pain model ) and the formalin test (representing an inflammatory tonic pain model ). T...

Background: The use of natural compounds in relieving pain has been commonplace since ancient times and their is currently increasing. Objectives: Given that analgesic anti-inflammatory effects Kombucha have not studied, this study was designed to examine these vitro. Methods: In experimental study, rats were divided into four groups. control group received normal saline i.p the same amount dru...

Introduction: The antinociceptive effect of morphine is, in part, mediated through the activation of a descending pathway. One of the major components of this pathway is the nucleus raphe magnus (NRM). Our previous study demonstrated the involvement of NRM in the analgesic effect of morphine microinjected into the nucleus cuneiformis (NCF) in a descending manner. The aim of the current study...

The limbic system has been implicated in the modulation of pain. The aim of this study was to determine the role of amygdala in different types of pain, viz., phasic and tonic. Unilateral stimulation of central nucleus of amygdala (CeA), basolateral nucleus (BL) and medial amygdaloid (MeA) in conscious rats resulted in the reduction of the tonic formalin-induced pain. The thresholds for simple ...

BACKGROUND Cisplatin is an effective antineoplastic drug used extensively in the treatment of malignancies. It induces painful peripheral neuropathy at high doses. OBJECTIVES The aim of this study was to investigate the effect of carbamazepine (CBZ) on cisplatin-induced peripheral neuropathic pain by using the tail-flick test. MATERIALS AND METHODS The study was performed using male Wistar ...