in this paper, cuo nanoparticles  have been synthesized via solid-state thermal decomposition using copper(ii) schiff base complexes as new precursors at 600ºc under air atmosphere for 3 h. surface morphology of the products were characterized by fourier transform infrared spectroscopy (ft-ir), x-ray diffraction (xrd) and scanning electron microscopy (sem).

Several different approaches exist to generate expressed RNA interference (RNAi) precursors for multiple target inhibition, a strategy referred to as combinatorial (co)RNAi. One such approach makes use of RNA Pol III-expressed long hairpin RNAs (lhRNAs), which are processed by Dicer to generate multiple unique short interfering siRNA effectors. However, because of inefficient intracellular Dice...

Dorsoventral patterning in Drosophila has long been known to involve a cascade of proteases, held in the inactive zymogen state prior to signaling. At long last, the prediction that a protease inhibitor is involved in this pathway has been shown to be true, with the identification of a serpin that plays a key part in Drosophila embryonic patterning.

Hydrocarbon Processing Industries (HPIs) emit large amounts of highly reactive hydrocarbons and Nitrogen Oxides to the atmosphere. Such simultaneous emissions of ozone precursors result in rapid and high yields ozone (O3) formation downwind. The climate of the Middle East has been shown to be favorable for O3 formation in summer. There are also vast activities in processing oil and gas in this ...

In this study, the concept of autoinhibition, a mechanism of protein activity regulation, was applied to the design and engineering of a β-lactamase zymogen. Using this zymogen, a sensitive protease assay method was developed in which activation of the zymogen by proteases produces an amplified absorbance signal. The approach reported here can be adapted for engineering of zymogens as biologica...

The three-dimensional structure of human procarboxypeptidase A2 has been determined using X-ray crystallography at 1.8 A resolution. This is the first detailed structural report of a human pancreatic carboxypeptidase and of its zymogen. Human procarboxypeptidase A2 is formed by a pro-segment of 96 residues, which inhibits the enzyme, and a carboxypeptidase moiety of 305 residues. The pro-enzyme...

Multiple species of bacteria are able to sequester the host zymogen plasminogen to the cell surface. Once localised to the bacterial surface, plasminogen can act as a cofactor in adhesion, or, following activation to plasmin, provide a source of potent proteolytic activity. Numerous bacterial plasminogen receptors have been identified, and the mechanisms by which they interact with plasminogen ...

Recent work from this laboratory has been concerned with elucidating the function of the non-thrombin-forming half or propiece of prothrombin in the zymogen activation process. These studies have demonstrated that Fragment 1, the NH2-terminal region of the propiece (Fragment 1.2), is responsible for the Ca2+-mediated binding of prothrombin to phospholipid vesicles (1) and that Fragment 2, the C...

Hydrocarbon Processing Industries (HPIs) emit large amounts of highly reactive hydrocarbons and Nitrogen Oxides to the atmosphere. Such simultaneous emissions of ozone precursors result in rapid and high yields ozone (O3) formation downwind. The climate of the Middle East has been shown to be favorable for O3 formation in summer. There are also vast activities in processing oil and gas in this ...