Data concerning circulating immune complexes were obtained for women who had had a pulmonary embolism, myocardial infarction, or cerebral thrombosis, and for 224 healthy controls. In women with pulmonary embolism who had used oral contraceptives concentrations of circulating immune complexes were significantly higher than in healthy controls (regardless of oral contraceptive use), or in those w...

Antiphospholipid syndrome (APS) is an autoimmune coagulation disorder that manifests clinically as venous and arterial thrombosis, and may affect any tissue or organ. Coronary artery involvement, however, is very rare. Case reports in the literature describing patients with coronary acute syndrome and APS treated with coronary angioplasty show conflicting results. We report an adult male patien...

AIMS Current non-invasive diagnostics for acute myocardial infarction (MI) identify myocardial necrosis rather than the primary cause and therapeutic target-plaque disruption and resultant thrombosis. The aim of this study was to identify changes specific to plaque disruption and pathological thrombosis that are distinct from acute myocardial necrosis. METHODS AND RESULTS We quantified 1,032 ...

Abbreviations: ACE trial 5 Acetylsalicylic Acid and Carotid Endarterectomy; ADP 5 adenosine diphosphate; AMP 5 adenosine monophosphate; CAPRIE study 5 Clopidogrel vs Aspirin in Patients at Risk of Ischemic Events; CI 5 confidence interval; COX 5 cyclooxygenase; DVT 5 deep venous thrombosis; EPISTENT trial 5 Evaluation of Platelet IIb/IIIa Inhibitors for Stenting; ESPS 5 European Stroke Preventi...

Abbreviations: ACE 5 ASA and Carotid Endarterectomy; BI 5 Barthel Index; CAPRIE 5 Clopidogrel vs Aspirin in Patients at Risk of Ischemic Events; CAST 5 Chinese Acute Stroke Trial; CI 5 confidence interval; CVST 5 cerebral venous sinus thrombosis; DVT 5 deep venous thrombosis; ECASS 5 European Cooperative Acute Stroke Study; ESPS 5 European Stroke Prevention Study; FDA 5 Food and Drug Administra...

New onset thrombocytopenia and multiple organ failure (TAMOF) presages poor outcome in critical illness. Patients who resolve thrombocytopenia by day 14 are more likely to survive than those who do not. Patients with TAMOF have a spectrum of microangiopathic disorders that includes thrombotic thrombocytopenic purpura (TTP), disseminated intravascular coagulation (DIC) and secondary thrombotic m...

Systemic lupus erythematosus (SLE), is sometimes complicated by the rare fatal syndrome, Thrombotic thrombocytopenic purpura (TTP), but the occurrence of TTP as the initial manifestation of SLE is very rare. Since they have similarities in some features, the differentiation of TTP from SLE may be missed. SLE patients are also more prone to thrombotic events. Here we report a case with TTP and d...

Essential thrombocythemia (ET) is a myeloproliferative neoplasm characterized by a clonal expansion of megakaryocytes. ET can result in both arterial and venous thrombosis. Involvement of the coronary arteries has been reported. Patients who harbor a CALR mutation are half as likely to suffer a thrombotic event as compared to patients with a JAK2 mutation. We report a case of CALR-mutated ET wh...