Intravesical instillation of thiotepa is a popular treatment for localized bladder carcinoma. The drug can enter the systemic circulation, and such absorption may be enhanced by extensive tumour infiltration or by a recent tumour resection. A case is reported of early onset life-threatening pancytopenia following an unusually low dose of the drug in a patient who had undergone a recent tumour r...

Specific interventions included in the review Various adjuvant treatments including chemotherapy, radiotherapy alone or in combination with chemotherapy, and chemoimmunotherapy. The drugs studied were: thiotepa, 5-fluorodeoxyuridine, mitomycin C, 5-fluorouracil, adriamycin, vincristine, cyclophosphamide, methyl CCNU, vinblastine, 1,3-bis(2 chlorethyl)-1-nitrosourea, tegafur, cytosine arabinosid...

OBJECTIVE Pericardial involvement is a common feature in different neoplastic diseases, having a strong influence on the natural history of the disease and on the quality of life of the patients. This study was performed in order to investigate the long-term effects of intracavitary treatment with thiotepa in the reduction of pericardial effusion (PE) recurrences. DESIGN Prospective controlle...

Aim—To investigate the eVects of single, short term (5 or 30 minutes) exposures to thiotepa or 5-fluorouracil (5-FU) on collagen lattice contraction and retinal pigment epithelial (RPE) cell proliferation. Methods—For collagen contraction studies, RPE cells seeded into free floating type I collagen lattices were exposed to single 5 or 30 minute treatments with thiotepa (0.06–4 mg/ml), or 5-FU (...

Abstract We report our experience treating 22 patients with newly diagnosed primary CNS diffuse B-cell lymphoma the MATRix regimen as reported by Ferreri, et al in 2016. The median age was 64 y (range 45-85); 10 were men and 12 women. Twenty had cerebral mass lesions, 1 a paraspinal mass, leptomeningeal disease. Treatment consisted of 4 cycles rituximab 375 mg/sq m (Days 1, 6); methotrexate 3.5...

Abstract We report our experience treating 20 patients with newly diagnosed primary diffuse B-cell lymphoma of the central nervous system MATRix regimen as reported by Ferreri, et al in 2016. The median age was 65 y; 8 were men and 12 women. Eighteen had cerebral mass lesions, 1 a paraspinal mass, leptomeningeal disease. Treatment consisted 4 cycles rituximab 375 mg/sq m (Days 1, 6); methotrexa...

Introduction: High-dose chemotherapy with autologous stem-cell transplantation (HDC-ASCT) is now the preferred consolidation strategy for young PCNSL patients. The optimal conditioning regimen unknown. data suggests that BEAM (carmustine, etoposide, cytarabine, melphalan) ineffective, BCNU/TT (carmustine/thiotepa) well-tolerated treatment related mortality (TRM) 1%–3%, but late relapses are com...