Main results 14 RCTs (1379 participants, 42% in 1 RCT) met the selection criteria. The quality of study methods was low (mean quality score 2.3 out of 5). Behaviour symptoms: methylphenidate was superior to placebo in 4 of 6 RCTs and to thioridazine in 1 RCT and was equivalent to imipramine in 1 RCT. Medication management was equivalent to combined medication and behavioural intervention; both ...

Main results 14 RCTs (1379 participants, 42% in 1 RCT) met the selection criteria. The quality of study methods was low (mean quality score 2.3 out of 5). Behaviour symptoms: methylphenidate was superior to placebo in 4 of 6 RCTs and to thioridazine in 1 RCT and was equivalent to imipramine in 1 RCT. Medication management was equivalent to combined medication and behavioural intervention; both ...

Our genomic profiling of patients with cutaneous T-cell lymphoma (CTCL) has revealed gain-of-function mutations in CARD11, but how this affects the CARD11-BCL10-MALT1 (CBM) complex CTCL is unknown. Overexpression CBM been reported adult (ATL) and diffuse large B-Cell (DLBCL), MALT1 inhibitors have shown efficacious decreasing cell proliferation inducing apoptosis ATL DLBCL lines overexpressing ...

Permanent cell culture lines derived from human breast cancer tissue are important experimental models in the study of human breast cancer cell proliferation. In the present work, pimozide, thioridazine, W-13, and W-12 were shown to inhibit MCF-7 human breast cancer cell growth. The 50% inhibition concentration values determined in two proliferation assays, | 'Hjthymidine incorporation and cell...

S udden death resulting from medications prescribed with good intentions is an everpresent threat first recognized nearly a century ago (1,2). As early as 1923, when quinidine was first used as antiarrhythmic therapy, a disturbing phenomenon was noted: some patients treated with quinidine suffered from sudden collapses, sometimes ending in unexpected deaths (2). These events were first attribut...

The adverse effects or overdose of thioridazine including sudden death, fatal arrhythmia, or retinopathy, in addition to the neurological signs have been reported. A three-year-old boy with bronchitis was prescribed erythromycin by a local clinic, but he started to complain of severe drowsiness and became unconscious. It was decided that this was a result of a compounding error of thioridazine ...