We studied the actions of Sch 50971, a novel histamine H3 receptor agonist, in an experimental neurogenic model of migraine and characterized its sedative and respiratory actions. Sch 50971 (i.v. and p.o) inhibited plasma protein extravasation in the dura mater of guinea pigs after electrical stimulation of the trigeminal ganglia. The minimum effective doses of Sch 50971 were 3.0 mg/kg i.v. and...

Starting from the well-known fact that the rolling movement always has a lower friction compared to sliding friction, the authors have conceived and realized a pivoting movement joint on a "layer of balls" with "compensation space", placed between the acetabular cup and the femoral head. This technical solution allows free self-directed migration of the balls, depending on the resistance oppose...

Total hydroxyproline/creatinine ratio (THP:Cr) was measured in random urine specimens from 18 infants with gastroenteritis. THP:Cr was sometimes increased during the acute phase of the illness and the reasons for this are discussed. Seven patients failed to thrive after the acute phase and THP:Cr was low in all of these. The test appears to be a sensitive indicator of the onset of failure to th...

gIR _i shall be obliged, if you will kindly insert the following in your esteemed Journal, if you think it will interest your readers. I was called to see a case of serpent bite to a village about 14 miles away. I reached the place at 2 p.m., and on inquiry I learnt that the man was bitten by a snake in the early morning of the previous day at 5 a.m., i-s,, thiity-three hours before I first saw...

Zymosan and carrageenan represent two inflammatory stimuli leading to significant neutrophilia when injected into mice. Despite several similarities between the two proinflammatory agents, the mechanisms leading to neutrophil influx into the site of stimulus injection are unclear. As demonstrated by antibody (Ab) studies directed against adhesion molecules, L-selectin was pivotal for zymosan-in...

Background: Production of N-alpha-methyl-histamine (NAMH), a histamine H3 receptor (H3R) agonist, is reportedly promoted in Helicobacter pylori infected human gastric mucosa. NAMH was suggested to act directly on histamine H2 receptors (H2Rs) in animals to stimulate acid secretion and to be a H2R agonist. As H2Rs and H3Rs play different roles in gastric acid secretion, it is very important to v...

Li, Mingkai, Jing Hu, Zhong Chen, Jia Meng, Haifang Wang, Xue Ma, and Xiaoxing Luo. Evidence for histamine as a neurotransmitter in the cardiac sympathetic nervous system. Am J Physiol Heart Circ Physiol 291: H45–H51, 2006. First published January 6, 2006; doi:10.1152/ajpheart.00939.2005.—The colocalization of histamine (HA) and norepinephrine (NE) immunoreactivities was identified within the s...

An asymmetric synthesis of 14-methyl-1-octadecene, the sex pheromone of the peach leafminer moth has been achieved. The target molecule was synthesized in six linear steps and in 30.3% overall yield from commercially available hexanoyl chloride, (S)-4-benzyloxazolidin-2-one and 1,9-nonanediol. The hexanoyl chloride was connected with (S)-4-benzyloxazolidin-2-one, and with the induction of the c...

rT~11 \ rTTT Dci/^Kiotru nrrrontcpH b\\J thp The VIII World Congress of Psychiatry organised by the World Psychiatric Association, took place at the Peace and Friendship Stadium, Athens, Greece from 12th to 19th October, 1989. The theme of the meeting was "Psychiatry Today?accomplishments and promises". Over 8000 delegates, primarily psychiatrists, from 72 countries and over 2500 trade delegate...