Matching 2-D gel electrophoresis images is the first and a major step in bioinformatics study of protein. This paper presents an improved implementation of a thin-plate spline image registration. The effectiveness of the algorithm is demonstrated on matching 2-D gel protein separation profiles.

We give some empirical comparisons between two nonparametric regression methods based on regularization: the elastic or thin-plate splines, and plastic splines based on total variation penalties. 1. Nonparametric regression with elastic and plastic splines We seek f to fit the dependence of response points zi ∈ R on two-dimensional covariates (xi, yi) living in the domain Ω. To this end, we emp...

In this study we consider the performance of different feature detectors used as the basis for the registration of images from two-dimensional gel electrophoresis. These are three spot detectors also used to identify proteins, and two domain independent keypoint detectors. We conduct a case study with images from a publically available data set which are synthetically distorted using thin plate...

A new multivariate approximation scheme to scattered data on arbitrary bounded domains in Rd is developed. The approximant is selected from a space spanned (essentially) by corresponding translates of the ‘shifted’ thin-plate spline (‘essentially,’ since the space is augmented by certain functions in order to eliminate boundary effects). This scheme applies to noisy data as well as to noiseless...

We consider the problem of data interpolation or smoothing using a thin-plate spline approach. The thin-plate spline formulation involves the linear combination of logarithmic kernels. For problems with large data sets, current methods for evaluating the splines are too slow. Recently, Beatson and Newsam 1] have suggested using a form of multi-pole type technique for the rapid evaluation of thi...

We describe a new approach to modelling pearlescent paints based on decomposing paint layers into stacks of imaginary thin sublayers. The sublayers are chosen so thin that multiple scattering can be considered across different sublayers, while it can be neglected within each of the sublayers. Based on this assumption, an efficient recursive procedure of assembling the layers is developed, which...

In surgery one of the major problems is a safe approach of the operation site. For surgeons it is paramount to know the location of surgically relevant nerves and vessels. Especially in surgery of the lateral (outside) foot, the anatomy is not always completely clear since the location of nerves and vessels is highly variable. Therefore CASAM is developed by students in Delft and Rotterdam (Net...

• Deals with problem of corresponding open curves where endpoints are not defined (ie best correspondence would involve missing of end parts of some curves) • Uses thin-plate spline bending energy to measure quality of correspondence • Treats problem in pairwise manner • Initial landmarks can slide along boundary to minimise obj.fn. • Seems to fix one shape as template, clip a proportion off an...

A novel elastic image registration approach is proposed, which can register both 2D medical images and gel electrophoresis automatically and accurately. Firstly, the global affine registration method based on image intensity is used to initialise a starting estimation of the robust registration algorithm. Then, by using iterative landmark based algorithm, the affine registration results are reg...