Tropical formulations of 5-trifluoromethyl-2'-deoxyuridine (TFT) containing different concentrations of TFT, Azone (Nelson Research and Development, Irvine, Calif.), and propylene glycol were evaluated for their potential efficacy in the treatment of cutaneous herpes simplex virus infections by in vitro studies of TFT penetration through skin and in vivo studies of therapeutic activity against ...

The synthesis of propylene oxide from propylene glycol, a derivative of bio-glycerol, was firstly realized in the presence of alkali-loaded silica catalysts to achieve 44% conversion and 70% selectivity.

An adjuvant composition containing a) one or more alkyl glucamides of the formula (I), wherein R1 represents a linear or branched alkyl group having 5 to 9 carbon atoms, R2 represents an alkyl group having 1 to 3 carbon atoms; b) at least one water-soluble ammonium salt, preferably selected from the group consisting of ammonium sulfate, ammonium nitrate, ammonium nitrate urea, ammonium phosphat...

Experimental solubilities of four antiepileptic drugs, that is, lamotrigine, diazepam, clonazepam, and phenobarbital in propylene glycol + water mixtures at 298.15 K were reported. The solubility of drugs was increased with the addition of propylene glycol, and the maximum values are observed in neat propylene glycol. The Jouyban-Acree model was used to fit the experimental data, and the solubi...

In recent years, the demand for thin film coatings on large area substrates has been rapidly increasing. Coating is some times required to make an object harder, or to provide the surface with particular electrical and optical properties. Hence, research on thin film science has received much attention due to its tremendous applications in modern technology. The importance of coatings and the s...

Venlafaxine representing a new class of antidepressants is a potent serotonin/ norepinephrine reuptake inhibitor. Transdermal delivery of venlafaxine hydrochloride (VHCl) may result in proper patient compliance by reducing the incidence of the undesirable GI problems generally associated with its plural oral dosing. The present study is an attempt to investigate the improvement of the transderm...

Now a day transdermal drug deliveries are increasing rapidly for the treatment of various diseases so the present study was conducted on different penetration enhancers for permeation of antidiabetic drug, glipizide (sulfonyl urea derivative) through skin. Different types of penetration enhancers such as terpenes and terpenoids, pyrrolidones, oxazolidinones, fatty acids etc are used for permeat...

Gaston, Lamont W. (National Heart Institute, National Institutes of Health, Bethesda, Md.) and E. R. Stadtman. Fermentation of ethylene glycol by Clostridium glycolicum, sp. n. J. Bacteriol. 85:356-362. 1963.-An anaerobic organism which utilizes ethylene glycol as a source of energy and carbon has been isolated from mud. It is a long (5 mu), slender, motile, gram-positive, spore-forming rod, wi...

BACKGROUND Dry eye disease (DED) is multifactorial, affecting 5-34 % of the global adult population and reducing quality of life. The artificial tears or lubricants are the therapy most used for the treatment of DED, due to their low side effect profile, which attempt to modify the properties of the tear film. The aim of the present study was to evaluate the clinical efficacy of a fixed combina...

Propylene glycol (PG) is a solvent commonly used in medications that, while benign at low doses, may cause toxicity in adults and children at high doses. We describe a case and the physiologic sequelae of propylene glycol toxicity manifested in a critically ill adolescent male with refractory myoclonic status epilepticus aggressively treated with multiple PG-containing medications (lorazepam, p...