نتایج جستجو برای: thiazolidine 4 ones
تعداد نتایج: 1407163 فیلتر نتایج به سال:
Antioxidants play an important role in inhibiting and scavenging radicals, thus providing protection to humans against infections and degenerative diseases. The present article focuses on the synthesis and antioxidant activity studies of a variety of 2-aryl thiazolidine -4-carboxylic acids. A series of twenty fully characterized 2-aryl thiazolidine-4-carboxylic acids have been synthesized by nu...
A facile synthesis of azabicycloadducts is described by 1,3-dipolar cycloaddition reactions of thioisatin with thiazolidine-2-carboxylic acid in the presence of various electron rich and electron deficient dipolarophiles. Theoritical calculations have been performed to study the regioselectivity of products. The geometrical and energetic properties have been analyzed for the different reactants...
Insulin-like growth factor-1 receptor (IGF-1R) is a growth factor receptor tyrosine kinase acting as a critical mediator of cell proliferation and survival. Novel 5-benzylidenethiazolidine-2,4-dione (5) and 5-(furan-2-ylmethylene)thiazolidine-2,4-dione (6) compounds were identified as potent and selective IGF-1R inhibitors via hierarchical virtual screening. Initial SAR and biological activity ...
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