نتایج جستجو برای: thiazole derivatives
تعداد نتایج: 106335 فیلتر نتایج به سال:

 1,3-Thiazole is one of the most attractive cores in heterocycles chemistry and drug discovery. Its widespread use diverse medicinal substances makes thiazole a versatile scaffold, which leads to novel generation efficient pharmaceuticals. This study was intended synthesize series N,N-disubstituted aminothiazole derivatives having various fragments at 4th 5th positions ring. The formation...
Synthesis and preliminary biological evaluation of imidazo (2, 1-b) Thiazole derivatives is reported. Under Mannich conditions, a series new were synthesized. Starting from the reaction 2- amino thiazole with 4- bromo phenyl bromide to produce 5-(4-bromo phenyl) thiazoles, following by introduce substituted aminomethyl at position 6-by reacting different aromatic amines under conditions afford ...
quinazolinones are a group of fused heterocyclic compounds which have valuable biological properties including cytotoxic, antibacterial and antifungal activities. thiazole group-containing compounds have been also reported to have a wide range of biological activities such as antitumor, anti-inflammatory, analgesic and antibacterial effects. due to valuable cytotoxic effects of both thiazole gr...
In recent years, the spread of drug-resistant strains of Streptococcus pneumoniae, as the most common causes of bacterial respiratory infections, threatens public health. Therefore, the use of new antimicrobial medicines to inhibit this pathogen is an urgent demand. In this research project, the inhibitory effects of thirty recently synthesized compounds including thiazole, thiazolidine, imidaz...
Tetrahydro-4H-chromene-3-carbonitrile derivatives 4a-c where prepared from the reaction of 1,4-cyclohexane dione (1), malononitrile (2) and either benzaldehyde (3a), 2-chlorobenzaldehyde (3b) or 4-methoxybenzaldehyde (3c) in ethanol containing triethylamine. Compound 4b was used to prepare pyrazole, pyrimidine thiazole derivatives. Moreover, tetrahydrobenzo[d]thiazole derivative 18 (1) with ele...
New series of thiazole derivatives were synthesized using 5-(aryldiazo)salicylaldehyde thiosemicarbazones 2a–i. Cyclocondensation 2a–i with chloroacetone afforded the corresponding 4-methylthiazole 3a–i. Moreover, cycloalkylation ethyl bromoacetate thiazolidin-4-one 4a–i. The antimicrobial activity new was evaluated.
A series of heteroaryl-substituted bis-trifluoromethyl carbinols were prepared and evaluated as malonyl-CoA decarboxylase (MCD) inhibitors. Some thiazole-based derivatives showed potent in vitro MCD inhibitory activities and significantly increased glucose oxidation rates in isolated working rat hearts.
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