Ten novel 4-(4,6-dimethoxypyrimidin-2-yloxy)phenoxy acetates and 4-(4,6-dimethylpyrimidin-2-yloxy)phenoxy acetates were synthesized with hydroquinone, 2-methylsulfonyl-4,6-disubstituted-pyrimidine and chloroacetic ester as starting materials. The products were characterized by IR, (1)H-NMR, MS spectra and elemental analyses. Preliminary bioassay indicates that the target compounds possess high ...

A series of ethyl 2-[2-arylamino-4-(thiophen-2-yl)thiazol-5-yl] acetates (5a-5k) and ethyl 2-[2-(arylhydrazino)-4-(thiophen-2-yl)thiazol-5-yl] acetates (9a-9g) were synthesized and screened for their anti-inflammatory, analgesic, and antioxidant activities. In vivo test results showed that the compounds with halogen substitution (5c, 5g, 5h, 5i and 5j) at the para position on the 2-aryl amino g...

Research and development of renewable resources are highly relevant today because of the limited supply of oil and its emission of greenhouse gases. New sustainable material has to be found and the idea of this project is to investigate and create possible conditions for a polymer made of the renewable resource betulin. Betulin is a naturally occurring triterpene in birch bark. A combination of...

Fungus growth methods for estimating either vitamin B1 thiazole or vitamin B1 pyrimidinel have been used by Robbins and Kavanagh (l), Kavanagh (2), and Krampitz and Woolley (3), and a fermentation stimulation method has been described by Schultz, Atkin, and Frey (4). A procedure utilizing the synthesis of vitamin B1 by yeast from thiazole and pyrimidine has been used in this laboratory to estim...

Potential of acetates and related compounds in glacial acetic acid as a catalyst for aldol-type condensation reactions was examined. Reactions of cycloalkanones or selected heteroaromatics with aldehydes in presence of 10 mol% of various acetates in acetic acid afforded α,α'-bis(substituted-benzylidene)cycloalkanones and substituted-benzylidene-mackinazolinones, respectively, in good yields. Am...

The structure of ethyl 2-amino-4-tert-butyl-1,3-thiazole-5carboxylate, C10H16N2O2S, (I), and the structure of the 1:1 adduct 6-methylimidazo[2,1-b]thiazole±2-amino-1,3-thiazole (1/1), C6H6N2S C3H4N2S, (II), have been determined. The molecules in (I) associate via a hydrogen-bonded R2(8) dimer consisting of NÐH N interactions, with the hydrogenbonding array additionally involving NÐH O interacti...

This paper describes the results obtained on the preparation of films composed of linter cellulose and the corresponding acetates. The acetylation was carried out in the LiCl/DMAc solvent system. Films were prepared from a LiCl/DMAc solution of cellulose acetates (degree of substitution, DS 0.8-2.9) mixed with linter cellulose (5, 10 and 15 wt %). Detailed characterization of the films revealed...

The first allylic carbonylation reaction of allylic acetates with aryl boronic acids under carbon monoxide has been developed. Using Pd-PCy3 as a catalyst, a wide spectrum of allylic acetates was carbonylated in the presence of various aryl boronic acids, affording α,β-unsaturated aryl ketones in good to excellent yields. Preliminary studies indicate that carbon monoxide always inserts at the l...

Background: Rhodoccocus equi, Brucella abortus, and Pasteurella multocida are important veterinary bacterial pathogens that in recent years have been resisted to current antibiotics, and this problem threats the livestock industry. To control this resistant microorganisms, use of new antibacterial compounds, such as thiazole derivatives, in veterinary is necessary. OBJECTIVES: In this study, an...