1Department of Molecular Biology of Trypanosoma cruzi, Instituto de Investigaciones Medicas Alfredo Lanari (IDIM, UBA-CONICET), Avenida Combatientes de Malvinas 3150, 1427 Buenos Avies, Argentina 2 Instituto de Ciencias Biomedicas, Universidade de São Paulo, Av. Lineu Prestes 1374, Cidade Universitária Butanta, São Paulo, CEP 05508-900, Brazil 3Deptartemento Biologia Celular e Inmunologia, Inst...

Enzymes or biocatalysts are produced in the human body from amino acids that the body obtains by digesting food proteins. Enzymes accelerate and control all biochemical processes in the body and in a single second several millions of enzyme mediated chemical reactions occur in a human body. Each enzyme is programmed to carry out one special task. The immense number of enzymes acts as a perfectl...

it is believed that the inhibition of carbohydrate hydrolyzing enzymes including α-amylase and α-glucosidase is one of the therapeutic approaches to decrease the postprandial glucose level after a meal, especially in the people with type 2 diabetes. medicinal plants and their extracts are one of the main sources to find new inhibitors to the enzymes. in our study four flavonoids, namely luteoli...

The posttranslational modification of therapeutic proteins with terminal sialic acids is one means of improving their circulating half-life, thereby improving their efficiency. We have developed a two-step in vitro enzymatic modification of glycoproteins, which has previously only been achieved by chemical means [Gregoriadis G, Jain S, Papaioannou I, Laing P (2005) Int J Pharm 300:125-130). Thi...

Metabolic enzymes have been known to carry out a variety of functions besides their normal housekeeping roles known as "moonlighting functions." These functionalities arise from structural changes induced by posttranslational modifications and/or binding of interacting proteins. Glycolysis is the sole source of energy generation for malaria parasite Plasmodium falciparum, hence a potential path...

There have been recent renewed interests in the importance of suicide enzyme inhibition. The principal objective this review is to investigate all types inhibitions for natural enzymes, artificial biocatalysts as well therapeutic potential It discussed inhibition beneficial drug design and treatments non-beneficial achievements some industrial enzymes such HRP peroxidase enzyme. biomimetic expl...

Background: Medical use of ionizing radiation has direct/indirect undesirable effects on normal tissues. In this study, the radioprotective effect of arbutin in megavoltage therapeutic x-irradiated mice was investigated using serum alkaline phosphatase (ALP), alanine aminotransferase (ALT), and asparate amniotransferase (AST) activity measurements. Material and Methods: In this analytical...