نتایج جستجو برای: the c3435t mdr1 polymorphism
تعداد نتایج: 16069836 فیلتر نتایج به سال:
In our previous paper, the chemosensitivity of human colorectal adenocarcinoma was evaluated against 12 anticancer drugs including 5-fluorouracil (5-FU), 7-ethyl-10-hydroxycamptothecin (SN-38), mitomycin C (MMC) and cisplatin (CDDP), and it was found that the anticancer drugs were effective against those with a relatively high growth rate. MMC was effective for those with a relatively high mRNA...
Background: Genetic variation that modifies the gut barrier function or the inflammatory response may modify the risk of colorectal cancer (CRC). The intestinal xenobiotic transporters, Multidrug Resistance 1 (MDR1/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2) contribute to the intestinal homeostasis by exporting a broad spectrum of substrates including potential carcinogens from the...
Background: Genetic variation that modifies the gut barrier function or the inflammatory response may modify the risk of colorectal cancer (CRC). The intestinal xenobiotic transporters, Multidrug Resistance 1 (MDR1/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2) contribute to the intestinal homeostasis by exporting a broad spectrum of substrates including potential carcinogens from the...
OBJECTIVE Guanfacine has been shown to reduce hyperactive behaviors in children with attention-deficit/hyperactivity disorder (ADHD) and possibly in children with pervasive developmental disorder (PDD) and hyperactivity. The aim of this exploratory study was to examine whether gene variants encoding the multidrug resistance protein (MDR1 or ABCB1) , a drug transporter at the blood-brain barrier...
P-glycoprotein (P-gp) is encoded by the MDR1 gene and involved in pharmacokinetics of drugs. The best-known polymorphisms are 1236C>T, 3435C>T, 2677G>T/A, which associated with protein folding, changes mRNA levels, drug pharmacokinetics. aim this study was to identify frequency distribution functional C1236T, C3435T, G2677T/A their haplotypes Uzbekistan. For research, peripheral blood samples w...
BACKGROUND Variations in the expression and activity levels of the multidrug-resistance MDR1/ABCB1 encoded P- glycoprotein (P-gp) have an impact on the therapeutic efficacy of many drugs. C3435T and G2677 polymorphisms of the MDR1/ABCB1 gene correlate with cellular expression levels of P-gp, a membrane-bound efflux pump which removes a multitude of drugs, including chemotherapy drugs and immuno...
Introduction Juvenile idiopathic arthritis (JIA) is one of the most common rheumatic disease in children. Brug of choice is methotrexate (MTX) cytostatic drug from the group of antimetabolites, folic acid antagonists. According to various authors, about 70% of patients receiving therapy with MTX are in remission for the disease. In 1988, MTX was approved FDA (Food and Drug Administration, USA) ...
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