نتایج جستجو برای: th22

تعداد نتایج: 272  

2015
Yazhong Tao Xin Zhang Robert Zivadinov Michael G. Dwyer Cheryl Kennedy Niels Bergsland Deepa Ramasamy Jacqueline Durfee David Hojnacki Brooke Hayward Fernando Dangond Bianca Weinstock-Guttman Silva Markovic-Plese

OBJECTIVES To assess potential roles of effector cells and immunologic markers in demyelinating CNS lesion formation, and their modulation by interferon β-1a (IFN-β-1a). METHODS Twenty-three patients with relapsing-remitting multiple sclerosis (RRMS) received IFN-β-1a for 6 months. Immunologic marker results were correlated with brain MRI lesion volumes, and volumes of normal-appearing brain ...

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Journal: :International Archives of Allergy and Immunology 2014

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Journal: :World Journal of Gastroenterology 2015

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2014
Nicolás Gonzalo Núñez Ana Tereza Nadan Louis Pérol Maud Milder Sophie Viel Philippe De La Rochere Philippe Delphine Loirat Sastre-Garau Xavier Christine Sedlik Sebastian Amigorena Eliane Piaggio

Introduction In human breast cancer, the invasion of tumor-draining lymph nodes (TDLNs) is an important step in disease progression and has predictive value [1]. TDLN dendritic cells (DCs), which are comprised of lymphoid-organ-resident and skin-derived migratory DCs, present tumor antigens to the naïve T cells and induce their activation and polarization into different functional subsets (Th1,...

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Journal: :Arthritis Research & Therapy 2013

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Journal: :Medical Science Monitor 2018

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2013
Nathella Pavan Kumar Rathinam Sridhar Vaithilingam V. Banurekha Dina Nair Mohideen S. Jawahar Thomas B. Nutman Subash Babu

BACKGROUND Th1 and Th17 responses are known to play an important role in immunity to pulmonary tuberculosis (PTB), although little is known about their role in extrapulmonary forms of tuberculosis (TB). METHODS To identify the role of Th1, Th17, and Th22 cells in multi-focal TB lymphadenitis (TBL), we examined mycobacteria-specific immune responses in the whole blood of individuals with PTB (...

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Journal: :The Journal of infectious diseases 2011
Bridgett Ryan-Payseur Zahida Ali Dan Huang Crystal Y Chen Lin Yan Richard C Wang William E Collins Yunqi Wang Zheng W Chen

BACKGROUND Malaria and AIDS represent 2 leading causes of death from infectious diseases worldwide, and their high geographic overlap means coinfection is prevalent. It remains unknown whether distinct immune responses during coinfection with malaria and human immunodeficiency virus (HIV) affect clinical outcomes. METHODS We tested this hypothesis by employing macaque models of coinfection wi...

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2013
Jianfei Yang Jill Skepner Mark Trocha Shomir Ghosh

Naïve CD4+ T helper cells can differentiate into Th1, Th2, Th17, T regulatory, Th9 and Th22 cells. Th1 cells are characterized by their production of IFNγ but not IL-4 and IL-5 while Th2 cells are characterized by their expression of IL-4 and IL-5 but not IFNγ. T-bet and GATA3 are the master transcription factors for Th1 and Th2 cells, respectively [1]. Th1 cells mediate cellular immunity again...

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2011
Qi Wan Lina Kozhaya Aimee ElHed Radha Ramesh Thaddeus J. Carlson Ivana M. Djuretic Mark S. Sundrud Derya Unutmaz

Human memory T cells (T(M) cells) that produce IL-17 or IL-22 are currently defined as Th17 or Th22 cells, respectively. These T cell lineages are almost exclusively CCR6(+) and are important mediators of chronic inflammation and autoimmunity. However, little is known about the mechanisms controlling IL-17/IL-22 expression in memory Th17/Th22 subsets. We show that common γ chain (γc)-using cyto...

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