Novel overlapping subgraph clustering for the detection of epitopes from an antigen Liang Zhao1,2, Shaogui Wu2, Jiawen Jiang1, Wencui Li1, Jie Luo1,*, Jinyan Li3, ∗ 1Taihe Hospital, Hubei University of Medicine, Hubei 442000, China. 2School of Computing and Electronic Information, Guangxi University, Nanning 530004, China. 3 Advanced Analytics Institute and Centre for Health Technologies, Unive...

Transglutaminase 2 (TGase 2) expression is increased in inflammatory diseases. We demonstrated previously that inhibitors of TGase 2 reduce nitric oxide (NO) generation in a lipopolysaccharide (LPS)-treated microglial cell line. However, the precise mechanism by which TGase 2 promotes inflammation remains unclear. We found that TGase 2 activates the transcriptional activator nuclear factor (NF)...

Objective: Clear genotype-phenotype associations in ichthyosis have been difficult to establish. We aimed expand the genotypic and phenotypic spectra of delineate associations. Design: recruited an international group individuals with ichthyosis, including participants all ages, races, ethnicities. Genetic analysis saliva or blood, a phenotyping questionnaire, standardized clinical photographs ...

Keratosis follicularis spinulosa decalvans (KFSD) is a rare cornification disorder with an X-linked recessive inheritance in most cases. Pathogenic variants causing KFSD have been described MBTPS2 , the gene for membrane-bound zinc metalloprotease that involved cleavage of sterol regulatory element binding proteins important control transcription. Few families identified autosomal dominant KFSD...

In this study, we verified the effects of 2-aza-8-oxohypoxanthine (AOH) on human epidermal cell proliferation by performing DNA microarray analysis. Cell was assessed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, which measures mitochondrial respiration in normal keratinocyte (NHEK) cells. Gene expression levels were determined analysis 177 genes involved skin aging ...

Transglutaminase 1 (TGase 1) is one of the genes implicated in autosomal recessive congenital ichthyosis. Skin from TGase 1(-/-) mice, which die as neonates, lacks the normal insoluble cornified envelope and has impaired barrier function. Characterization of in situ dye permeability and transepidermal water loss revealed defects in the development of the skin permeability barrier in TGase 1(-/-...

136 Chelated zinc, copper, and manganese compared to sulfates improve eggshell breaking strength and tibia trace mineral con­ centration in laying hens. S. P. Bai1, G. Jin1, D. L. Li1, Y. H. Luo1, K. Y. Zhang*1, F. J. Ji2, H. Cao2, and M. K. Manangi2, 1Institute of Animal Nutrition, Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan Agricultural Unive...