background: cutaneous leishmaniasis is a neglected parasitic disease, which imposes massive human distress and financial costs to the endemic countries. better understanding of host immune response to the parasite leads to helpful strategies for disease control. interleukin (il)-10 and transforming growth factor (tgf)-β are important immune regulatory cytokines, which appear to develop non-heal...

AIMS Secreted modular calcium-binding protein 1 (SMOC1) is a matricellular protein that potentially interferes with growth factor receptor signalling. The aim of this study was to determine how its expression is regulated in endothelial cells and its role in the regulation of endothelial cell function. METHODS AND RESULTS SMOC1 was expressed by native murine endothelial cells as well as by cu...

Pulsed electromagnetic fields (PEMFs) have been documented to promote bone fracture healing in nonunions and increase lumbar spinal fusion rates. However, the molecular mechanisms by which PEMF stimulates differentiation of human bone marrow stromal cells (hBMSCs) into osteoblasts are not well understood. In this study the PEMF effects on hBMSCs were studied by microarray analysis. PEMF stimula...

It is currently unknown how mucosal adjuvants cause induction of secretory immunoglobulin A (IgA), and how T cell-dependent (TD) or -independent (TI) pathways might be involved. Mucosal dendritic cells (DCs) are the primary antigen presenting cells driving TI IgA synthesis, by producing a proliferation-inducing ligand (APRIL), B cell activating factor (BAFF), Retinoic Acid (RA), TGF-β or nitric...

background: successful pregnancy in allopregnant women depends upon the control of graft rejection mechanisms. it has been suggested that some immunosuppressive cytokines contribute to successful pregnancy and transplantation. transforming growth factor beta (tgf-   β) exhibits potent immunoregulatory and anti-inflammatory properties which might prolong graft survival. recent studies suggest a ...

Background: Breast cancer initiates when normal breast epithelial cells begin to replicate unusually. These divide more rapidly than and continue be accumulated formed a lump or mass. Cells may migrate (metastasis stage) from tissues lymph nodes other human body parts. Cellular autophagy is one of the most critical mechanisms in development. Autophagy plays dual function as tumor support proces...

Increased collagen expression in tumors is associated with increased risk of metastasis, and triple-negative breast cancer (TNBC) has the highest propensity to develop distant metastases when there is evidence of central fibrosis. Transforming growth factor-β (TGF-β) ligands regulated by cancer-associated fibroblasts (CAFs) promote accumulation of fibrosis and cancer progression. In the present...

The TGF-β (transforming growth factor-β) cytokine superfamily in mammals contains some 30 members. These dimeric proteins are characterized by a strongly conserved cystine knot-based structure. They regulate the proliferation, differentiation and migration of many cell types, and therefore have important roles in morphogenesis, organogenesis, tissue maintenance and wound healing. Thus far, arou...