1. Collagenolytic activity towards acid-soluble collagen labelled with [(14)C]-proline was assayed in rat liver with and without carbon tetrachloride poisoning. The products of enzymic digestion were found to be free amino acids and peptides. 2. The hepatic collagenolytic activity increased under conditions of single-dose and subacute carbon tetrachloride poisoning, and correlated with hydroxyp...

5 min after intravenous injection into rats of (14)C- or (36)Cl-carbon tetrachloride, liver lipids were found labeled. Most of the radioactivity was found in the phospholipid fraction. The metabolites were shown to comprise a heterogeneous group of branched long-chain chlorinated fatty acids, probably containing the trichloromethyl side chain. Surviving liver slices also formed these metabolite...

A force matching technique based on previous work by Voth and co-workers is developed and employed to coarse grain intermolecular potentials for three common solvents: carbon tetrachloride, benzene, and water. The accuracy of the force-matching approach is tested by comparing radial distribution functions (RDF) obtained from simulations using the atomistic and coarse-grained potentials. Atomist...

In this study, PMC (2,2,5,7,8-pentamethyl-6-hydroxychromane), a derivative of alpha-tocopherol, dose-dependently (1-10 mg/kg) ameliorated the increase in plasma aspartate aminotransferase (GOT) and alanine aminotransferase (GPT) levels caused by chronic repeated carbon tetrachloride (CCl4) intoxication in mice. Moreover, PMC significantly improved the CCl4-induced increase of hepatic glutathion...

The study of tautomerics equilibria is vital importance as tautomeric compounds reactivity highly depends on the proportion each tautomer. Herein, equilibrium 3-phenyl-2,4-pentanedione was studied theoretically by b3lyp/6-31+g(d)methods. effect four solvents considered (water, methanol, carbon tetrachloride and Cyclohexane).The takes place through four-membered ring transition state. barrier he...

Protective effect of ethanolic extract of polyherbalformulation (PHF) of three medicinalplants was studied on carbon tetrachloride induced liver damage in rats. Treatment with 250mg I kg b.w. of ethanolic extract of PHF protected rats against carbon tetrachloride liver injury by significantly lowering 5'NT, GGF, GDH and SDH and bilirubin levels compared to control group of rats. Normalising the...

Previously, we described the generation and initial characterization of four Tn5 mutants of Pseudomonas stutzeri strain KC with impaired ability to degrade carbon tetrachloride (Sepúlveda-Torres et al., 1999). In this study, we show cloning and sequencing of an 8.3 kbp region in which all four transposons were located. This fragment encodes eight potential genes and is located in the central pa...

Inula cappa is well known for its medicinal properties like anti-inflammatory, digestive, depurative, carminative, analgesics, antipyretics, treatment of peptic ulcer etc. The present study focuses on the ability of I. cappa to alleviate liver damage caused by over carbon tetrachloride. The aqueous extract of whole plant of I. cappa (400 mg/kg, p.o) significantly showed hepatoprotective activit...