AIM To identify and characterize a novel gene with potential roles in testis development and spermatogenesis. METHODS A cDNA microarray was constructed from a human testis large insert cDNA library and hybridized with probes of human or mouse adult and fetal testes. Differentially expressed genes were isolated and sequenced. RT-PCR was used to test the tissue distribution of the genes of inte...

Background: Alcohol affects reproduction in both men and women in a number of ways. Chronic exposure to ethanol may results in pathophysiologic changes in cellular function. The present work was designed to investigate the morphology of testis submitted to experimental ethanol ingestion. Materials and Methods: Twenty adult male mice were divided in 2 groups: control sham (salin normal) and test...

In this study we report a case of cavernous hemangioma of the testis, which mimicked a testicular teratoma. A 42-year-old male presented with a left testicular swelling that had arisen suddenly and been present for three months. Scrotal ultrasound revealed a hypoechoic mass with several calcifications in the left testicle. The mass demonstrated blood flow in the color Doppler mode. A radical or...

This study was organized to see whether vitamin E, as a strong antioxidant, could affect the abnormalities of testis structure caused by para-nonylphenol (p-NP) during its development. A total of 32 female Wistar rats after mating were divided into four groups (n = 8): control, vitamin E (100 mg kg(-1) per day), p-NP (250 mg kg(-1) per day) and p-NP + vitamin E. The rats were treated from the s...

The tissue expression patterns of 10 mouse testis cDNAs were analysed by RT-PCR to search for new mammalian meiotic genes. The homologue of the rat synaptonemal complex protein gene SCP1 is expressed in embryonic ovary, adult brain and testis. One novel gene is stringently testis specific and another is expressed exclusively in testis and embryonic ovary. The latter clone is not expressed in th...

Interest in the mechanism leading to the formation of the germline and its differentiation during Drosophila development, initiated even as soon as the first ever cloned tumour suppressor gene in Drosophila, the lethal (2) giant larvae (lgl), had been identified. Further work has shown that the lgl, as well as discs large-1 (dlg) and scribble (scrib) tumor suppressor genes code for scaffolding ...

Adenocarcinoma of the rete testis is an exceptionally rare and malignant testicular neoplasm. Although treatment of pregnant women with diethylstilbestrol (DES) results in reproductive tract abnormalities in their male offspring, increased incidence of testicular tumors has not been verified. However, recently three cases of seminoma have been described in men prenatally exposed to DES, suggest...

background: quantum dots (qds) are new types of fluorescent materials for biological labeling. qds toxicity study is an essential requirement for future clinical applications. therefore, this study aimed to evaluate cytotoxic effects of cdse: zns qds on male reproductive system. materials and methods: in this experimental study, the different concentrations of cdse: zns qds (10, 20 and 40 mg/kg...

CASE REPORT A 2-week-old boy was referred to our hospital for evaluation of left cryptorchidism. He was a result of a full-term normal pregnancy. The infant was well developed proportional to his age. On genital examination, the right testis was in normal size and located in the scrotum, but the left testis was not palpable in the scrotum. No other physical abnormalities were detected. Outpatie...

A patient with bilateral cryptorchism had ectopic splenic tissue adherent to his left testicle and an adrenal cortical rest adherent to his right testicle. The embrylogic basis for these disorders is discussed and the literature reviewed.