The objective of the current study was to determine the role of transforming growth factor beta (TGFb) during seminiferous cord formation and embryonic testis development. The expression pattern of mRNA for TGFb isoforms was evaluated during testis development through a quantitative reverse transcriptionpolymerase chain reaction (QRT-PCR) procedure. Expression of mRNA for TGFb1 was highest at p...

Cisplatin is an effective chemotherapeutic drug used to treat many types of tumours. However, it may cause male reproductive toxicity. Gallic acid exhibits beneficial effects such as antioxidant, anti-inflammatory and antitumor. The current study investigated the gallic against testis epididymis toxicity induced by cisplatin. Male rats were divided into 4 groups follows (n = 7): Control, cispla...

The mammalian testis is a complex organ that serves two important functions, synthesis of steroids, with significant amount of estrogenic hormones produced and production of spermatozoa. Estrogen receptors (ERs) are expressed in cells of the testis as well as the epididymal epithelium. We have demonstrated that estrogen receptor expression is higher in reproductive tissues as compared to non-re...

background: the effects of electromagnetic field (emf) on reproductive system have been of critical concern for a long time. it has been shown that the emf can adversely affect testicular cells and tissue and decrease male fertility. the most important determinants of male fertility are sperm development and motility, which are affected by changes in several factors including lipocalin 2 protei...

background: trifluralin is a herbicide and used in agriculture widely. it enters plants through developing roots and stops plant cells from division and elongation (meristemic inhibitor). extensive application of trifluralin to control annual grasses and broadleaf weeds in agriculture, horticulture and horn garden, leads to environmental pollution and its entrance into the food chain could have...

The objective of the current study was to extend previous observations and examine the expression pattern and effects of transforming growth factor alpha (TGFalpha) and epidermal growth factor receptor (EGFR) on embryonic testis morphogenesis and growth. The expression of TGFalpha was determined after morphological sex determination (seminiferous cord formation at embryonic day 13 [ED13]) throu...

The silk dye effluent is one of the most potential harmful chemicals liberated in environment an unexpected manner. Silk waste widely used as a potent dyeing yarn and fabrics many countries has been shown to produce some adverse health effects. This work focuses primarily on effects Moringa oleifera leaf extract testis induced surface ultrastructure Swiss albino mice Mus musculus. taken account...

Background: The effects of electromagnetic field (EMF) on reproductive system have been of critical concern for a long time. It has been shown that the EMF can adversely affect testicular cells and tissue and decrease male fertility. The most important determinants of male fertility are sperm development and motility, which are affected by changes in several factors including lipocalin 2 protei...

In the present research we have investigated the distribution of the sugar residues of the glycoconjugates in the prepubertal and postpubertal testes of a subject with Morris's syndrome (CAIS, Complete Androgen Insensitivity Syndrome). For this purpose a battery of six horseradish peroxidase-conjugated lectins was used (SBA, PNA, WGA, ConA, LTA and UEAI). We have obtained a complete distributio...

background: it is proved that testis is sensitive to electromagnetic field (emf) and its damage results in infertility. exposure to emf induces reactive oxygen species production and affects on anti-oxidants defense mechanisms. metallothionein (mt) is a name for a group of low molecular weight (6-7 kda), sulfhydryl rich proteins. expression of mt1 and mt2 genes in testis tissue after emf exposu...