BACKGROUND The aim of this study was to assess the use of testicular sperm for ICSI in azoospermic men with hypogonadotrophic hypogonadism unresponsive to gonadotrophin therapy. METHODS Fifteen patients with hypogonadotrophic hypogonadism who remained azoospermic after hormonal treatment underwent testicular sperm extraction (TESE) and ICSI. These men were recruited from the Egyptian IVF cent...

background: pentoxifylline (px) is a methyxanthin derivative that influences the sperm motion characteristics. in general, px has been reportedly effective in preserving sperm motility in vitro, also when administered orally to the asthenozoospermic patients. objective: the main objective of this prospective clinical trial study was to rule out the effect of oral administration of px on sperm p...

Recovery of testicular spermatozoa from azoospermic patients with testicular failure, followed by intracytoplasmic sperm injection (ICSI) is a recent advance in the treatment of male infertility. In most cases, free spermatozoa are recovered from testicular tissue after mechanical mincing of multiple biopsies. Testicular sperm retrieval, however, remains unsuccessful in 30-50% of male patients ...

PURPOSE Although optimizing endogenous testosterone production before testicular sperm extraction is commonly practiced, whether improved preoperative testosterone levels enhance sperm retrieval remains unclear. We evaluated the influence of preoperative medical therapy in men with nonobstructive azoospermia before microdissection testicular sperm extraction. MATERIALS AND METHODS A total of ...

background: we performed this study to evaluate use of fresh and frozen sperm samples in non-obstructive azoospermia microdissection testicular sperm extraction (micro-tese-icsi) treatment. methods: we performed a total of 82 consecutive in vitro fertilization (ivf) cycles at fertijin ivf center in istanbul, turkey from january 2010 to march 2012. in 43 participants we used fresh sperm and froz...

USING EPIDIDYMAL AND TESTICULAR SPERM FROM AZOOSPERMIC MEN: THE CLEVELAND CLINIC EXPERIENCE Mehmet Oder, Ramadan A Saleh, Namita Kattal, Mohamed A Bedaiwy, Anthony J Thomas, Ashok Agarwal, Cleveland Clinic Foundation Objective: Sperm retrieval from testis and epididymis, combined with ICSI, has significantly enhanced the chances of azoospermic men to father their own genetic offspring. The impa...

When ejaculates from rival males compete for fertilization, there is strong selection for sperm traits that enhance fertilization success. Sperm quantity is one such trait, and numerous studies have demonstrated a positive association between sperm competition and both testes size and the number of sperm available for copulations. Sperm competition is also thought to favor increases in sperm qu...

Patients with non-obstructive azoospermia (NOA) were once considered to be infertile with few treatment options due to the absence of sperm in the ejaculate. In the last two decades, the advent of intracytoplasmic sperm injection (ICSI), and the application of various testicular sperm retrieval techniques, including fine needle aspiration (FNA), conventional testicular sperm extraction (TESE) a...

It is often questioned whether sperm parameters, including whether retrieved or ejaculated, have any effect on intracytoplasmic sperm injection (ICSI) results. Do severe spermatogenic defects affect embryo quality or pregnancy rate? Further, does it matter in azoospermic patients whether the sperm source is testicular or epididymal? Our studies show there is no significant difference in results...

Spermatogenic damage may occur after vasectomy, and the damage is pressure mediated, occurring when the occluded reproductive tract is unable to accommodate additional sperm produced by the testis. This study aimed to determine the long-term effect of vasectomy on spermatogenesis in humans and clarify how the balance between sperm production in the testis and sperm storage in or removal from th...