1Department of Urology, Gulf Medical College Hospital & Research Center, 2Dept. of Pathology, Gulf Medical University, Ajman, UAE. Correspondence: Dr. Ihsan Ullah Khan, Department of Urology, Gulf Medical College Hospital & Research Center, Ajman, UAE. email: [email protected] INTRODUCTION Testicular tumors are rare in children, but highly treatable and usually curable. In children testicular...

OBJECTIVE To find out the mode of presentation, age distribution and the prevalence of various histological subtypes of testicular tumors. METHOD All consecutive cases of testicular tumors diagnosed in the department of pathology, the Aga Khan University Hospital, Karachi, during the period of eight years (1991-98) were included in this study. Relevant clinical details such as age, clinical p...

Testicular germ cell tumors are important neoplasms and seminoma accounts for 40 to 50% of these tumors. Little is known concerning the molecular events underlying the development of these malignancies. In the present study we used a modified differential display approach to compare gene expression between seminoma and normal testicular parenchyma, both of which are mixed tissues. We first anal...

Received October 2007 Accepted June 2008 INTRODUCTION Leydig cell tumors (LCTs) are the most common stromal tumors, accounting for 3% of all testicular neoplasms.(1) Approximately, 3% of the LCTs are bilateral.(1) They may be hormonally active, leading to either feminizing or virilizing syndromes. About 10% of them are malignant.(1) The diagnosis of a malignant LCT is not always easy, because n...

Testicular teratomas may present in both prepubertal and adult males. The prognosis differs greatly between these two groups. In children, teratomas most often occur before the age of four. They are seen in their pure form, and behave a benign behavior. In adults, teratomas are usually part of a mixed GCTs, and have the potential to metastasize. The presence of neck metastasis in patients with ...

The incidences of all primary neoplasms in the testes and accessory reproductive organs of 51,230 male Fischer 344 (F344) rats and 46,752 male B6C3F1 mice were obtained from the pathology data base of more than 300 long-term toxicity/carcinogenicity studies performed for the National Toxicology Program. The overall incidence of reproductive system neoplasms in male F344 rats was 81.5%. The most...

The incidence of secondary neoplasms of the testis during autopsies is approximately 2.5%. Although most secondary testicular metastases are due to prostate cancer, only a few patients with prostate cancer have clinically manifested testicular metastasis. We report the case of a prostate cancer patient with testicular metastasis who was diagnosed after the presence of a palpable mass in the rig...

BACKGROUND Germ-cell testicular cancer has not been definitively linked to any known hereditary cancer susceptibility disorder. Familial testicular cancer in the presence of other findings in affected and unaffected family members might indicate a previously-unidentified hereditary cancer syndrome. CASE PRESENTATION The patient was diagnosed with a left testicular seminoma at age 28, and trea...

Historical data are presented for neoplasms and related proliferative lesions from 1,170 Sprague-Dawley rats that served as controls in 9 carcinogenicity (2 year) studies conducted in the Safety Evaluation Facility of Ciba-Geigy Corporation, Summit, New Jersey. The most common neoplasm was pituitary adenoma, which occurred in 62.2% of the male and 84.7% of the female rats. Incidences of other n...