The reactive intermediate generated by the addition of tert-butyl and 1,1,3,3-tetramethyl butyl isocyanide and cyclohexyl isocyanide to dialkyl acetylenedicarboxylate was trapped by 3-hydroxy pyridine to produce highly functionalized 4H-chromenes in fairly good  yields

methyl tert-butyl ether (mtbe), a gasoline octane enhancer, was introduced as a substitute for lead tetraethyl over 30 years ago. widespread use of mtbe in gasoline, has introduced mtbe into the environment compartments, mostly into the under ground and surface water and water as a second most frequently detected contaminant. in this study, we have isolated pure cultures from bacterial consorti...

The reactions of [(thf)2TiCl4] with sodiated 2,2’-bis[2-hydroxy-3,5-di(tert-butyl)benzylideneamino]-1,1’-biphenyl (1 a) and 2,2’-bis[2-hydroxy-3,5-di(tert-butyl)benzylideneamino]-4,4’-dimethyl-1,1’-biphenyl b) yield the corresponding Ti complexes 2 a b. Similarly, 1 reacts [(thf)2ZrCl4] to Zr derivative 3. For a, mixture cis-β trans isomers were observed in solution whereas congener exclusively...

(2S,4R)- and (2S,4S)-perfluoro-tert-butyl 4-hydroxyproline were synthesized (as Fmoc-, Boc-, and free amino acids) in 2-5 steps. The key step of each synthesis was a Mitsunobu reaction with perfluoro-tert-butanol, which incorporated a perfluoro-tert-butyl group, with nine chemically equivalent fluorines. Both amino acids were incorporated in model α-helical and polyproline helix peptides. Each ...

3-Iodo-5-phenylisothiazole-4-carbonitrile 1 reacts with tert-butyl carbazate via a Buchwald C-N style coupling to afford tert-butyl 3-(4-cyano-5-phenylisothiazol-3-yl)carbazate 2 in 70% yield.

Robust analytical methods were developed for the determination of eight emerging synthetic phenolic antioxidants (SPAs) and three metabolites in sewage sludge, effluent and river water matrices. Accelerated solvent extraction was employed for the extraction of the target analytes from sludge, dichloromethane/hexane=3:1 (extraction solvent) and 90°C (extraction temperature) were used after optim...

Using solid-state 1H nuclear magnetic resonance (NMR) spin-lattice relaxation experiments, we have investigated the effects of several solid-solid phase transitions on tert-butyl and methyl group rotation in solid 1,3,5-tri-tert-butylbenzene. The goal is to relate the dynamics of the tert-butyl groups and their constituent methyl groups to properties of the solid determined using single-crystal...

With the development of a novel microwave-assisted one-pot tandem de-tert-butylation of tert-butyl amine in an Ugi-type multicomponent reaction product, tert-butyl isocyanide as a useful convertible isonitrile has been explored for the first time affording access to molecular diversity of pharmaceutically-important polycyclic N-fused imidazo-heterocycles.

Tetrathiafulvalene (TTF), pentacene, and quarterthiophene with tert-butyl substituents are synthesized, and the crystal structures and the transistor properties are investigated. The tetracyanoquinodimethane (TCNQ) complex of tert-butyl TTF constructs highly one-dimensional segregated columns with tetragonal crystal symmetry.

Submit Manuscript | http://medcraveonline.com Abbreviations: ANVISA: National Health Surveillance Agency; BHA: mixture of 2-tert-butyl-4-hydroxyanisole and 3-tert-butyl4-hydroxyanisole; BHT: 3,5-di-tert-butyl-4-hydroxytoluene; CGMS: Gaseous Chromatography coupled to Mass Spectrometry; HPLC: High Pressure Liquid Chromatography; PG: Propyl 3,4,5-trihydroxybenzoate or Propyl Gallate; TBHQ: Tertbut...